SNP information rs17782313

Research and publications:

  18454148   Common variants near MC4R are associated with fat mass, weight and risk of obesity

  18682847   Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

  18697794   The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.

  19016587   How does body fat influence bone mass in childhood? A Mendelian randomization approach

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19073769   Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes

  19079261   Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  19153581   Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.

  19164386   Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.

  19197348   Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

  19255736   Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

  19265794   Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.

  19470880   Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

  19526209   Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

  19553259   Common body mass index-associated variants confer risk of extreme obesity

  19557197   NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

  19629057   Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.

  19668254   Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19812171   Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.

  19822564   Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types

  19844209   Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.

  19880856   Life course variations in the associations between FTO and MC4R gene variants and body size

  19906786   Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach

  19910641   Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus

  19915463   Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes.

  20017980   A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.

  20061430   Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.

  20070976   Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth.

  20092643   Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

  20127379   From monogenic to polygenic obesity: recent advances.

  20161779   Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

  20181787   A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake.

  20215774   Association between a common variant near MC4R and change in body mass index develops by two weeks of age.

  20386550   Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.

  20397748   Genome-wide association study of height and body mass index in Australian twin families.

  20406574   Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior.

  20520848   Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.

  20616199   Evaluation of genetic susceptibility loci for obesity in Chinese women.

  20616999   Usefulness of Mendelian randomization in observational epidemiology.

  20712903   Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study

  20724578   Evaluation of A2BP1 as an obesity gene.

  20724581   Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.

  20725061   MC4R variant is associated with BMI but not response to resistance training in young females.

  20816152   Obesity and diabetes genetic variants associated with gestational weight gain.

  20816195   Analyses of shared genetic factors between asthma and obesity in children.

  20824172   Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

  20843981   Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children.

  20966902   Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

  21063808   Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations.

  21085626   Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.

  21147891   Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study.

  21150882   Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.

  21152014   Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.

  21210875   Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults.

  21267540   Genetic predisposition to obesity leads to increased risk of type 2 diabetes.

  21283731   FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

  21293879   A dynamic model for genome-wide association studies.

  21303735   Association study of MC4R with complex obesity and replication of the rs17782313 association signal.

  21347432   The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women.

  21357383   No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.

  21372613   Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention.

  21466928   Genetics and epigenetics of obesity.

  21526213   Genetic markers of obesity risk: stronger associations with body composition in overweight compared to normal-weight children.

  21544599   Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth.

  21573225   Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine.

  21593506   Maternal and offspring adiposity-related genetic variants and gestational weight gain.

  21688152   Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk.

  21695122   Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

  21701570   Genome-wide association of BMI in African Americans.

  21750520   Implication of European-derived adiposity loci in African Americans.

  21773002   Mendelian Randomisation Study of Childhood BMI and Early Menarche.

  21785715   Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.

  21787115   CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk.

  21799482   Common genetic variants and central adiposity among Asian-Indians.

  21818152   Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.

  21976109   Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study.

  22029802   Genetic risk score does not correlate with body mass index of Latina women in a clinical trial.

  22043165   Genetics of Obesity: What have we Learned?

  22051089   Associations of obesity genes with obesity-related outcomes in multiethnic children.

  22083549   Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty.

  22310352   Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene.

  22328972   A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.

  22350153   A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population.

  22384102   A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study.

  22421923   Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians.

  22466342   β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.

  22511254   Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies.

  22614171   Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

  22869321   Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23049848   Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.

  23054017   The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan.

  23073174   From genotype to human β cell phenotype and beyond

  23094032   Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study.

  23101478   Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

  23130628   Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low.

  23147118   Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review.

  23201545   FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention.

  23236435   Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2.