SNP information rs1229984

Research and publications:

  2398055   Expression and kinetic characterization of variants of human beta 1 beta 1 alcohol dehydrogenase containing substitutions at amino acid 47.

  2547609   The genes for human alcohol dehydrogenases beta 1 and beta 2 differ by only one nucleotide.

  6374651   Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.

  10090900   Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.

  11545539   ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students.

  12050823   A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.

  12244546   Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population.

  12452180   Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations.

  15534263   Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.

  15863807   Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism.

  15911586   Effects of natural selection on interpopulation divergence at polymorphic sites in human protein-coding Loci.

  16255080   A haplotype map of the human genome.

  16614111   Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.

  16685648   Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.

  17185388   Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.

  17273965   Evidence of positive selection on a class I ADH locus.

  17718394   The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.

  17847010   Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia.

  17923853   Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes.

  18056758   Major genetic components underlying alcoholism in Korean population.

  18331377   Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.

  18382665   Ethnic related selection for an ADH Class I variant within East Asia.

  18500343   Multiple ADH genes are associated with upper aerodigestive cancers.

  18518925   Genetic susceptibility to heroin addiction: a candidate gene association study.

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  18996923   Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.

  19124091   Distribution of the alcohol dehydrogenase ADH1B*47His allele in Eurasia.

  19193628   ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.

  19262484   Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.

  19298322   Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.

  19486361   Alcohol dehydrogenase 2 genotype and risk for migraine.

  19526455   ADH1A variation predisposes to personality traits and substance dependence.

  19687126   A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

  19698717   Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

  19737746   Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.

  19826048   Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran

  19861527   Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.

  20089146   The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.

  20100738   Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.

  20158305   Associations between ADH gene variants and alcohol phenotypes in Dutch adults.

  20205700   Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.

  20219057   ADH1B*2 allele is protective against alcoholism but not chronic liver disease in the Hungarian population.

  20332099   A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

  20336794   A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.

  20505153   A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

  20585100   Genome-wide association studies of cancer.

  20700531   The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.

  20810466   Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001.

  20833657   Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.

  21083667   Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.

  21143251   A candidate gene association study of alcohol consumption in young women.

  21168396   Variation in the ADH1B proximal promoter affects expression.

  21303386   Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador.

  21338875   Genetic vulnerability and susceptibility to substance dependence

  21351086   Shortened telomeres in individuals with abuse in alcohol consumption.

  21372407   Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.

  21378355   Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.

  21437268   A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21497796   Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.

  21576033   ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.

  21592108   Diversification of the ADH1B gene during expansion of modern humans.

  21635275   Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample.

  21807602   Cross-comparison of the genome sequences from human, chimpanzee, Neanderthal and a Denisovan hominin identifies novel potentially compensated mutations.

  21895720   Alcohol dehydrogenase-1B Arg47His polymorphism and upper aerodigestive tract cancer risk: a meta-analysis including 24,252 subjects.

  21900886   Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study.

  21917409   Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers.

  21926110   Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.

  21940907   Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer.

  21968928   ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.

  22048268   Combined effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 alleles on alcoholism and chronic liver diseases.

  22052802   Gene-environment interactions of novel variants associated with head and neck cancer.

  22144473   Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

  22150722   ADH1B polymorphism, alcohol consumption, and binge drinking in Slavic Caucasians: results from the Czech HAPIEE study.

  22301922   Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges.

  22325912   Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey.

  22331481   Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

  22332091   Recent advances in understanding the role of nutrition in human genome evolution.

  22363810   Alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases: a prospective study and meta-analysis.

  22507220   Epidemiologic differences in esophageal cancer between Asian and Western populations.

  22560290   A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.

  22640768   The genetic basis of addictive disorders.

  22655231   Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

  22662130   Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method.

  22674868   Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China.

  22675424   ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.

  22690706   Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).

  22806211   The genetics of addiction-a translational perspective.

  22865593   Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.

  22930414   Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China.

  23088731   Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis.

  23149980   Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.

  23166662   Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study.

  23176670   High diversity and no significant selection signal of human ADH1B gene in Tibet.

  23414439   Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men.

  23430454   Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population.

  23456092   Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.

  23629646   Epidemiology of esophageal cancer in Japan and China.

  23701534   Genetic instrumental variable studies of effects of prenatal risk factors.

  23720673   Molecular epidemiology of DNA repair gene polymorphisms and head and neck cancer.