SNP information rs1051730

Research and publications:

  17135278   Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

  18385676   Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

  18385738   A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

  18385739   A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

  18414406   Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

  18519524   Variants in nicotinic receptors and risk for nicotine dependence

  18565990   Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

  18571741   Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research

  18618000   A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction

  18759969   In search of causal variants: refining disease association signals using cross-population contrasts

  18780872   Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

  18957677   The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer

  18978790   Lung cancer susceptibility locus at 5p15.33.

  19005185   Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese

  19010884   Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine

  19029397   Nicotinic receptor gene variants influence susceptibility to heavy smoking

  19064933   Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans

  19132693   Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence

  19247474   Genome-wide and candidate gene association study of cigarette smoking behaviors

  19259974   Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

  19300482   A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci

  19300500   A genome-wide association study of pulmonary function measures in the Framingham Heart Study.

  19423719   Update in lung cancer 2008.

  19429911   A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

  19436041   Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

  19443489   Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

  19465454   The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung

  19494806   Dopamine genes and nicotine dependence in treatment-seeking and community smokers.

  19569043   Genome-wide association studies and the genetic dissection of complex traits

  19628476   Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15

  19639606   Correcting the “winner's curse” in odds ratios based on genome-wide association results for major complex human diseases.

  19641473   Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  19733931   Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients

  19741265   Genetics and genomics of chronic obstructive pulmonary disease.

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19800047   Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.

  19836008   A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  19903803   Re: Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.

  19951401   Chronic obstructive pulmonary disease: towards pharmacogenetics

  20007924   The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema.

  20010834   Genome-wide association study identifies five loci associated with lung function.

  20010835   Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

  20068085   Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report.

  20142248   Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer.

  20147892   Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence

  20158304   A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.

  20159342   Genetics of addictions

  20348396   A general framework for studying genetic effects and gene-environment interactions with missing data.

  20393456   Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.

  20395203   A second genetic variant on chromosome 15q24-25.1 associates with lung cancer

  20418888   Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

  20418889   Meta-analysis and imputation refines the association of 15q25 with smoking quantity

  20418890   Genome-wide meta-analyses identify multiple loci associated with smoking behavior

  20485328   Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes

  20548021   Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium

  20554942   Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

  20564069   Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk.

  20581870   From smoking to lung cancer: the CHRNA5/A3/B4 connection

  20585100   Genome-wide association studies of cancer.

  20631687   Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility

  20643934   A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

  20656943   Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

  20700436   Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

  20736995   Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence

  20808433   Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population

  20832656   Genetics of addictions

  20886544   Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance

  21079997   Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence

  21081471   Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study

  21168125   TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood

  21191315   Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene

  21219822   [Recent progress in genetic variants associated with cancer and their implications in diagnostics development].

  21228559   A preliminary study of the CHRNA3-CHRNA5-CHRNB4 cluster, smoking and Parkinson's disease.

  21229299   Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

  21232152   Epidemiology, radiology, and genetics of nicotine dependence in COPD.

  21248747   Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population.

  21268243   Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy

  21296624   An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs.

  21320324   The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.

  21357676   Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.

  21385908   Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers

  21424681   Peripheral arterial disease in diabetes: is there a role for genetics?

  21430647   The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment

  21436384   Genetic variability of smoking persistence in African Americans

  21438146   Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders.

  21498873   Associations of nicotine intake measures with CHRN genes in Finnish smokers.

  21559498   Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

  21593077   Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

  21606948   Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes

  21645942   Association of smoking with tumor size at diagnosis in non-small cell lung cancer.

  21646606   Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study.

  21685187   Genome-wide association study of smoking behaviours in patients with COPD

  21690317   CHRNA3 rs1051730 genotype and short-term smoking cessation

  21697764   Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer

  21747048   Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.

  21748402   A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.

  21808284   Gender-stratified gene and gene-treatment interactions in smoking cessation.

  21858091   In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression.