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SNP information rs1049353

RS1049353

Normal allele: CC

Genetic variability in cannabinoid receptor 1 (CNR1) causes addiction to cannabis. Also associated with weight gain when taking neuroleptics.

Polymorphism rs1049353 is related to topics like this:

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...


Research and publications:

  16917946   Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.

  17292652   No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.

  17873324   The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men.

  17881126   No association of CNR1 gene variations with susceptibility to schizophrenia.

  17942526   Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis.

  18179391   Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.

  18213623   Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder.

  18579347   Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression.

  18606954   Cannabinoid receptor 1 gene association with nicotine dependence.

  18776593   Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population.

  19014633   Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa.

  19016476   Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

  19018721   Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.

  19052543   Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

  19093002   CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy.

  19165169   Variants in the CNR1 and the FAAH genes and adiposity traits in the community.

  19335651   Candidate genes for cannabis use disorders: findings, challenges and directions.

  19443135   The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.

  19659925   Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.

  19886064   Involvement of CNR1 gene polymorphisms in modulating the effects of the endocannabinoid system.

  19944766   A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia

  20033240   Eating disorders: the current status of molecular genetic research.

  20080186   Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.

  20107430   A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia.

  20192949   CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.

  20195480   Cannabinoid receptor 1 (CNR1) polymorphism 1359 G/A modulates susceptibility to ulcerative colitis and the Crohn's disease phenotype.

  20204253   G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2.

  20415562   Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity.

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20587580   Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution.

  20631561   Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain.

  20691427   Genetic associations of brain structural networks in schizophrenia: a preliminary study

  20838400   Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

  21129839   A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.

  21143251   A candidate gene association study of alcohol consumption in young women.

  21420833   Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.

  21477106   Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity.

  21633404   Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.

  21695734   Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain.

  21714860   Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces.

  21798285   Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.

  21808609   Components of cross-frequency modulation in health and disease.

  22085192   Cannabinoid receptor 1 gene is associated with alcohol dependence.

  22123166   Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence.

  22194214   Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes.

  22393204   Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression.

  22459871   A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research.

  22473907   P-selectin genotype is associated with the development of cancer cachexia.

  22567136   CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.

  22669173   Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users.

  22826533   Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes.

  22920733   Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-α gene (PPARA) and schizophrenia.

  23010766   Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1.

  23092589   Colorado Twin Registry: an update.

  23337343   Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and their influence on anthropometric parameters and metabolic parameters under a high monounsaturated vs. high polyunsaturated fat hypocaloric diets.

  23407780   Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.

  23422373   CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.

  23748922   A common functional promoter variant links CNR1 gene expression to HDL cholesterol level.

  23793356   Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.

  23799528   Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies.

  24172113   Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems.

  24180398   Endocannabinoid signaling in the etiology and treatment of major depressive illness.

  24286185   Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses.

  24319431   Mechanisms of antidepressant resistance.

  24322329   Role of genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) on weight loss and cardiovascular risk factors after liraglutide treatment in obese patients with diabetes mellitus type 2.

  24407958   Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures.

  24596569   Gene-environment interactions and intermediate phenotypes: early trauma and depression.

  24980155   Role of CNR1 polymorphisms in moderating the effects of psychosocial adversity on impulsivity in adolescents.

  25045619   The Genetics, Neurogenetics and Pharmacogenetics of Addiction.

  25093427   Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome.

  25116250   Genetic variability in the human cannabinoid receptor 1 is associated with resting state EEG theta power in humans.

  25136364   Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls.

  25252306   [Association study of CNR1, GAD1 and BDNF polymorphisms with male heroin dependence in the Dai population in Yunnan].

  25268406   Cannabinoid receptor gene polymorphisms and bone mineral density in Korean postmenopausal women.

  25368670   CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.

  25477898   Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.

  25664923   Association of G1359A polymorphism of the cannabinoid receptor gene (CNR1) with macronutrient intakes in obese females.

  26071625   Brain structural and clinical changes after first episode psychosis: Focus on cannabinoid receptor 1 polymorphisms.

  26131011   Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.

  26527537   The role of cannabinoid receptors in the processing of facial expressions in adolescents.

  26648684   Update on genetics and diabetic retinopathy.

  26753847   Parent and peer influences on emerging adult substance use disorder: A genetically informed study.

  27034934   Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms.

  27217270   Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis.

  27500453   Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate.

  27642547   Genetic and Environmental Factors Associated with Cannabis Involvement.

  27895608   Genetic Consideration of Schizotypal Traits: A Review.

  28099629   The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.

  28534260   Pharmacogenetics of Cannabinoids.

  28822116   Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.

  28930056   Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood.

  29353877   Gene variants and educational attainment in cannabis use: mediating role of DNA methylation.

  30016776   G1359A Variant of the Cannabinoid Receptor Gene (rs1049353) and Obesity-Related Traits and Related Endophenotypes: A Meta-Analysis.

  30129173   Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.

  30237658   Association between gene polymorphisms and obesity and physical fitness in Korean children.

  30239920   An endocannabinoid receptor polymorphism modulates affective processing under stress.

  30546300   Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks.

  30845666   Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System.

  31013550   Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme.

  31184938   CNR1 and FAAH variation and affective states induced by marijuana smoking.

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