Normal allele: CC
Genetic variability in cannabinoid receptor 1 (CNR1) causes addiction to cannabis. Also associated with weight gain when taking neuroleptics.
Polymorphism rs1049353 is related to topics like this:
Research and publications:
16917946 Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.
17881126 No association of CNR1 gene variations with susceptibility to schizophrenia.
17942526 Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis.
18213623 Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder.
18606954 Cannabinoid receptor 1 gene association with nicotine dependence.
19093002 CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy.
19165169 Variants in the CNR1 and the FAAH genes and adiposity traits in the community.
19335651 Candidate genes for cannabis use disorders: findings, challenges and directions.
19886064 Involvement of CNR1 gene polymorphisms in modulating the effects of the endocannabinoid system.
20033240 Eating disorders: the current status of molecular genetic research.
20192949 CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.
20587580 Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution.
20691427 Genetic associations of brain structural networks in schizophrenia: a preliminary study
21143251 A candidate gene association study of alcohol consumption in young women.
21714860 Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces.
21798285 Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.
21808609 Components of cross-frequency modulation in health and disease.
22085192 Cannabinoid receptor 1 gene is associated with alcohol dependence.
22473907 P-selectin genotype is associated with the development of cancer cachexia.
22567136 CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.
23010766 Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1.
23092589 Colorado Twin Registry: an update.
23422373 CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.
23748922 A common functional promoter variant links CNR1 gene expression to HDL cholesterol level.
23793356 Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.
24180398 Endocannabinoid signaling in the etiology and treatment of major depressive illness.
24319431 Mechanisms of antidepressant resistance.
24596569 Gene-environment interactions and intermediate phenotypes: early trauma and depression.
25045619 The Genetics, Neurogenetics and Pharmacogenetics of Addiction.
25268406 Cannabinoid receptor gene polymorphisms and bone mineral density in Korean postmenopausal women.
25368670 CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.
25477898 Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.
26131011 Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.
26527537 The role of cannabinoid receptors in the processing of facial expressions in adolescents.
26648684 Update on genetics and diabetic retinopathy.
26753847 Parent and peer influences on emerging adult substance use disorder: A genetically informed study.
27034934 Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms.
27642547 Genetic and Environmental Factors Associated with Cannabis Involvement.
27895608 Genetic Consideration of Schizotypal Traits: A Review.
28099629 The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.
28534260 Pharmacogenetics of Cannabinoids.
29353877 Gene variants and educational attainment in cannabis use: mediating role of DNA methylation.
30129173 Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.
30237658 Association between gene polymorphisms and obesity and physical fitness in Korean children.
30239920 An endocannabinoid receptor polymorphism modulates affective processing under stress.
30845666 Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System.
31184938 CNR1 and FAAH variation and affective states induced by marijuana smoking.