SNP information rs1045642

Research and publications:

  10716719   Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

  11502320   Frequency of C3435T polymorphism of MDR1 gene in African people

  12189368   Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein

  12686700   Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1

  15197162   Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.

  15452305   Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy

  15452306   Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy

  15805193   Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

  16912956   Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity

  16912957   Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration

  16999857   ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients.

  17146660   Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.

  17185560   A "silent" polymorphism in the MDR1 gene changes substrate specificity

  17366837   Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada

  17548681   MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.

  17674045   No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients

  17898703   Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.

  17913323   ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

  18182569   Pharmacogenetics of minimal residual disease in children with precursor acute lymphoblastic leukemia B: a report from the Children's Oncology Group.

  18213362   Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array.

  18285546   PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group

  18334914   Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration

  18424454   ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.

  18518969   Association of ABCB1 genetic variants with renal function in Africans and in Caucasians

  18547414   Genotyping panel for assessing response to cancer chemotherapy

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18725235   Bidirectional translational research: Progress in understanding addictive diseases.

  18784455   The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis

  18812236   No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.

  18831695   Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir

  18854777   Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  19155191   Opiate and cocaine addiction: from bench to clinic and back to the bench.

  19193698   Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate

  19197249   Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain

  19285141   Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response

  19373654   ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma

  19403460   Pharmacogenetics of antidepressant response: an update.

  19437139   ABCB1 single nucleotide polymorphisms in the Brazilian population.

  19442035   Pharmacogenomics of platinum-based chemotherapy in NSCLC.

  19514130   Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

  19617466   CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity

  19694740   No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

  19706858   Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

  19740399   Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant.

  19812066   Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women

  19819348   Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations.

  19890215   CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy.

  19896927   Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms.

  19916993   A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.

  19924384   Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors.

  19930591   Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

  19934400   Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

  20017669   Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique

  20170205   Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I.

  20177420   Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer

  20201854   Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.

  20214406   Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.

  20216335   Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).

  20354687   Explaining variability in ciclosporin exposure in adult kidney transplant recipients.

  20357209   Molecular genetic studies of gene identification for osteoporosis: the 2009 update

  20389299   Pazopanib-induced hyperbilirubinemia is associated with the UGT1A1 polymorphism of Gilbert's syndrome.

  20440227   Clopidogrel pathway

  20505666   Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients on cyclosporine therapy in a long-term follow-up.

  20531015   Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS

  20532504   Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin.

  20533057   ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.

  20602618   Irinotecan pharmacogenomics.

  20617924   Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS

  20628376   Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients.

  20696882   Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients

  20707787   Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting

  20801494   Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.

  20859246   ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment

  20921971   Mapping genes that predict treatment outcome in admixed populations.

  20948663   The ABCB1 transporter gene and antidepressant response.

  21048526   Doxorubicin pathways: pharmacodynamics and adverse effects.

  21102498   Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients.

  21122163   The pharmacogenetics of imanitib.

  21160409   Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population

  21172166   Pharmacogenetics of antidepressant response.

  21185600   Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia

  21197270   Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors

  21197301   Recent advances in the use of opioids for cancer pain.

  21219401   Evaluation of limited sampling methods for estimation of tacrolimus exposure in adult kidney transplant recipients.

  21247447   CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population

  21288825   Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.

  21289622   Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

  21311724   Genetic polymorphisms of ATP-binding cassette (ABC) proteins, overall survival and drug toxicity in patients with Acute Myeloid Leukemia.

  21332314   Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer

  21333900   The role of genetics in IBS

  21358751   Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness

  21364332   Ultra-resistant schizophrenia is not associated with the multidrug-resistant transporter 1 (MDR1) gene rs1045642 variant

  21383334   Lack of association of OPRM1 and ABCB1 single-nucleotide polymorphisms to oxycodone response in postoperative pain.

  21441680   Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians.

  21468756   The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients

  21544031   Expression of CYP3A5 and P-glycoprotein in renal allografts with histological signs of calcineurin inhibitor nephrotoxicity

  21553324   Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome.

  21615938   Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder.

  21673041   Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success.