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SNP information rs10273639

RS10273639

Normal allele: TT

PRSS1-PRSS2 variants encoding trypsin influence the risk of asparaginase-related pancreatitis.

Polymorphism rs10273639 is related to topics like this:

Hereditary pancreatitis

Pancreatitis is a multifaceted ailment that can stem from various sources. If pancreatitis arises...

Research and publications:

  24777884   High serum trypsin levels and the -409 T/T genotype of PRSS1 gene are susceptible to neonatal sepsis.

  25253127   Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.

  26149858   Genetic susceptibility factors for alcohol-induced chronic pancreatitis.

  26246244   Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639.

  26784911   Association Analysis of PRSS1-PRSS2 and CLDN2-MORC4 Variants in Nonalcoholic Chronic Pancreatitis Using Tropical Calcific Pancreatitis as Model.

  26820620   Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis.

  27846138   Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.

  28913878   Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.

  29884332   Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis.

  30467200   Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report.

  30524475   The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis.

  31163246   Effects of PRSS1-PRSS2 rs10273639, CLDN2 rs7057398 and MORC4 rs12688220 polymorphisms on individual susceptibility to pancreatitis: A meta-analysis.

  31900721   Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.

  32764075   Genetic associations of T cell cancer immune response-related genes with T cell phenotypes and clinical outcomes of early-stage lung cancer.

  35089416   Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.

  35226426   Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia.

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