SNP information rs10181656

Research and publications:

  17932559   Association of STAT4 with rheumatoid arthritis in the Korean population.

  18434327   Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility

  18516230   Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

  18579578   A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

  19120275   STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes.

  19333953   High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.

  19674979   Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

  19717398   Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort.

  19737838   A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor.

  19762360   A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus.

  19950257   Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines.

  20176035   Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease.

  20237121   Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.

  20444755   Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

  20454450   Evidence that STAT4 is a common autoimmune gene: rs7574865 is associated with Crohn's disease of the colon and early onset of the disease.

  20479942   Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  21120996   Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.

  21179067   A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

  21683716   Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population.

  22162633   Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.

  22328738   Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  22569826   Abnormal genetic and epigenetic changes in signal transducer and activator of transcription 4 in the pathogenesis of inflammatory bowel diseases.

  22753649   Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.

  23226040   Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies.

  23251581   Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades.

  24449572   Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

  25019342   Association between STAT4 gene polymorphisms and autoimmune thyroid diseases in a Chinese population.

  26880555   Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

  26895230   Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.

  27957241   Recent advances in the diagnosis and treatment of primary biliary cholangitis.

  28852993   STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders.

  30044774   Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population.

  32010893   Association of Signal Transducer and Activator of Transcription 4 rs10181656 Polymorphism With Rheumatoid Arthritis and Systemic Sclerosis in Khuzestan Province in Southwestern Iran.