Normal allele: TT
Variation in the cannabinoid receptor gene CNR1 increases the risk of cannabis dependence.
Polymorphism rs6454674 is related to topics like this:
Research and publications:
16917946 Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.
17509535 CNR1 variation modulates risk for drug and alcohol dependence.
17881126 No association of CNR1 gene variations with susceptibility to schizophrenia.
18213623 Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder.
18606954 Cannabinoid receptor 1 gene association with nicotine dependence.
19335651 Candidate genes for cannabis use disorders: findings, challenges and directions.
19886064 Involvement of CNR1 gene polymorphisms in modulating the effects of the endocannabinoid system.
21714860 Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces.
21798285 Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.
22085192 Cannabinoid receptor 1 gene is associated with alcohol dependence.
23422373 CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.
24180398 Endocannabinoid signaling in the etiology and treatment of major depressive illness.
25477898 Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.
27034934 Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms.
27642547 Genetic and Environmental Factors Associated with Cannabis Involvement.
28099629 The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.
28534260 Pharmacogenetics of Cannabinoids.
30845666 Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System.
34566715 FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality.
34786265 Diagnostic Challenges and Management of Fibromyalgia.
35327588 Biomarkers of the Endocannabinoid System in Substance Use Disorders.