SNP information rs588765

Research and publications:

  18414406   Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

  19029397   Nicotinic receptor gene variants influence susceptibility to heavy smoking

  19443489   Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  20159342   Genetics of addictions

  20395203   A second genetic variant on chromosome 15q24-25.1 associates with lung cancer

  20418889   Meta-analysis and imputation refines the association of 15q25 with smoking quantity

  20485328   Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes

  20554942   Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

  20584212   Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

  20587604   Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans

  20700436   Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

  20832656   Genetics of addictions

  21079997   Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence

  21229299   Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

  21385908   Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers

  21685187   Genome-wide association study of smoking behaviours in patients with COPD

  21858091   In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression.

  22042234   Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.

  22042774   Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.

  22176972   Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.

  22241830   Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

  22539395   Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

  22884254   Association of the nicotine dependence susceptibility gene, CHRNA5, with age at onset of Parkinson's disease: interaction of gene and smoking status.

  22899653   Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

  23011884   Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations.

  23249876   Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.

  23358500   Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content.

  23404318   Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals?

  23692359   CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

  23872218   Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.

  23875064   Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study.

  24055496   A glimpse into the future - Personalized medicine for smoking cessation.

  24186853   Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

  24588897   CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.

  24733007   Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers.

  24778978   Genetics and smoking.

  24934182   CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control.

  25036316   Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

  25051068   Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.

  25632390   Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study.

  25826680   Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers.

  25941207   An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School.

  26010901   Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking.

  26282330   The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15.

  26833182   Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.

  26942719   Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.

  26981579   Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.

  27166759   Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

  27197960   Association between variants in nicotinic acetylcholine receptor genes and smoking cessation in a Chinese rural population.

  27302872   Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD.

  28884473   Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers.

  29052254   Smoking-associated genetic polymorphisms predict risk of surgery in patients with Crohn's disease.

  31342675   Impact of CHRNA5 polymorphisms on the risk of schizophrenia in the Chinese Han population.

  31402126   Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer.

  32152934   Association of CHRNA5 Gene Variants with Crack Cocaine Addiction.

  34096587   Depressive Symptoms Predict Clinical Recurrence of Inflammatory Bowel Disease.