SNP information rs578776

Research and publications:

  17135278   Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

  18414406   Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

  18519524   Variants in nicotinic receptors and risk for nicotine dependence

  18565990   Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

  18571741   Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research

  18618000   A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction

  18780872   Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

  18783506   Association of single nucleotide polymorphisms in the neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and the “pleasurable high” during early smoking experiments.

  19029397   Nicotinic receptor gene variants influence susceptibility to heavy smoking

  19132693   Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence

  19184766   A testable prognostic model of nicotine dependence

  19247474   Genome-wide and candidate gene association study of cigarette smoking behaviors

  19259974   Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

  19436041   Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

  19443489   Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

  19596527   Nicotine dependence and genetic variation in the nicotinic receptors

  19628476   Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  20393456   Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.

  20418888   Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

  20485328   Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes

  20581870   From smoking to lung cancer: the CHRNA5/A3/B4 connection

  20584212   Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

  20587604   Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans

  20624154   Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes

  20631687   Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility

  20643934   A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

  20700436   Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

  20736995   Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence

  20808433   Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population

  20840187   Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence

  20886544   Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance

  21191315   Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene

  21228559   A preliminary study of the CHRNA3-CHRNA5-CHRNB4 cluster, smoking and Parkinson's disease.

  21229299   Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

  21385908   Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers

  21436384   Genetic variability of smoking persistence in African Americans

  21559498   Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

  21606948   Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes

  21685187   Genome-wide association study of smoking behaviours in patients with COPD

  21748402   A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.

  21808284   Gender-stratified gene and gene-treatment interactions in smoking cessation.

  21810735   Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.

  21862624   Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.

  21949713   Genetics of sputum gene expression in chronic obstructive pulmonary disease.

  22042234   Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.

  22046326   "Smoking genes": a genetic association study.

  22048466   Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.

  22176972   Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.

  22241830   Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

  22291610   A flexible Bayesian model for studying gene-environment interaction.

  22438921   Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.

  22438940   Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.

  22539395   Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

  22806211   The genetics of addiction-a translational perspective.

  22832964   Genome-wide meta-analyses of smoking behaviors in African Americans.

  22884254   Association of the nicotine dependence susceptibility gene, CHRNA5, with age at onset of Parkinson's disease: interaction of gene and smoking status.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23024249   Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.

  23143843   Molecular mechanisms underlying behaviors related to nicotine addiction.

  23249876   Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.

  23255854   A functional polymorphism in the CHRNA3 gene and risk of chronic obstructive pulmonary disease in a Korean population.

  23397474   Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population.

  23689675   Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.

  23691092   Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.

  23692359   CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

  23872218   Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.

  23875064   Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study.

  23943838   Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.

  24065931   The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers.

  24186853   Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

  24375168   ADHD diagnosis may influence the association between polymorphisms in nicotinic acetylcholine receptor genes and tobacco smoking.

  24588897   CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.

  25036316   Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

  25045619   The Genetics, Neurogenetics and Pharmacogenetics of Addiction.

  25051068   Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.

  25139936   Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study.

  25233467   Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.

  25471942   Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.

  25632390   Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study.

  25642160   Nicotinic receptor modulation to treat alcohol and drug dependence.

  25778907   The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.

  25874685   CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.

  25941207   An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School.

  26010901   Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking.

  26044620   Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.

  26351737   Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use.

  26695521   Is Mendelian Randomization the Key to Understanding Causal Aspects of Parkinson's Disease?

  26831765   Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis.

  26981579   Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.

  27127891   Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.

  27166759   Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

  27197960   Association between variants in nicotinic acetylcholine receptor genes and smoking cessation in a Chinese rural population.

  28069549   SNPs within CHRNA5-A3-B4 and CYP2A6/B6 are associated with smoking dependence but not with tobacco dependence treatment outcomes in the Czech population.

  28827732   Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.

  29749891   The DRD2/ANKK1 Taq1A polymorphism is associated with smoking cessation failure in patients with coronary heart disease.

  30777653   Genetic variants of nicotinic receptors and smoking cessation in Parkinson's disease.