Normal allele: GG
5082;A single nucleotide polymorphism in the alpha 5 subunit of the neuronal acetylcholine receptor (CHRNA5) is associated with smoking status and "pleasurable high" during early smoking experiments.
Research and publications:
18519524 Variants in nicotinic receptors and risk for nicotine dependence
18780872 Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
19029397 Nicotinic receptor gene variants influence susceptibility to heavy smoking
19184766 A testable prognostic model of nicotine dependence
19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors
19596527 Nicotine dependence and genetic variation in the nicotinic receptors
20393456 Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.
20418888 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
20581870 From smoking to lung cancer: the CHRNA5/A3/B4 connection
20587604 Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans
20643934 A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction
20808433 Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population
21191315 Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene
21228559 A preliminary study of the CHRNA3-CHRNA5-CHRNB4 cluster, smoking and Parkinson's disease.
21229299 Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers
21436384 Genetic variability of smoking persistence in African Americans
21559498 Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk
21606948 Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes
21685187 Genome-wide association study of smoking behaviours in patients with COPD
21748402 A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.
21808284 Gender-stratified gene and gene-treatment interactions in smoking cessation.
21862624 Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
21949713 Genetics of sputum gene expression in chronic obstructive pulmonary disease.
22042234 Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.
22046326 "Smoking genes": a genetic association study.
22291610 A flexible Bayesian model for studying gene-environment interaction.
22438921 Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.
22806211 The genetics of addiction-a translational perspective.
22832964 Genome-wide meta-analyses of smoking behaviors in African Americans.
22992668 Pharmacogenomics knowledge for personalized medicine.
23024249 Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.
23143843 Molecular mechanisms underlying behaviors related to nicotine addiction.
23249876 Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.
23397474 Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population.
23872218 Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.
24065931 The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers.
24186853 Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
24588897 CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.
25045619 The Genetics, Neurogenetics and Pharmacogenetics of Addiction.
25642160 Nicotinic receptor modulation to treat alcohol and drug dependence.
26351737 Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use.
26695521 Is Mendelian Randomization the Key to Understanding Causal Aspects of Parkinson's Disease?
26831765 Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis.
26981579 Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.
30777653 Genetic variants of nicotinic receptors and smoking cessation in Parkinson's disease.