SNP information rs4939827

Research and publications:

  17934461   A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

  18372901   Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

  18372905   A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

  19011631   Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

  19155440   Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.

  19357349   Association of common genetic variants in SMAD7 and risk of colon cancer.

  19395656   The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.

  19786869   Recent insights into the pathogenesis of colorectal cancer.

  20124488   Increased risk of colon cancer associated with a genetic polymorphism of SMAD7.

  20368424   Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.

  20407467   Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14.

  20501757   Low-penetrance susceptibility variants in familial colorectal cancer.

  20505153   A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

  20530476   Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population.

  20560206   Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data.

  20585100   Genome-wide association studies of cancer.

  20628028   Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

  20648012   Association studies on 11 published colorectal cancer risk loci.

  20659471   Genetic heterogeneity in colorectal cancer associations between African and European americans.

  20688557   The Yin and Yang of bone morphogenetic proteins in cancer.

  21036793   Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field

  21068203   Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.

  21071539   Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

  21075068   SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study.

  21097774   Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in Lynch syndrome.

  21119214   Colorectal cancer susceptibility loci in a population-based study: Associations with morphological parameters.

  21179028   Replication study of SNP associations for colorectal cancer in Hong Kong Chinese.

  21219822   [Recent progress in genetic variants associated with cancer and their implications in diagnostics development].

  21221812   A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population.

  21242260   Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

  21314996   Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

  21357381   Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study.

  21387313   Genetic variation in bone morphogenetic protein and colon and rectal cancer.

  21655089   Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.

  21761138   Meta-analysis of new genome-wide association studies of colorectal cancer risk.

  21910156   Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women.

  22045029   Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.

  22235025   Susceptibility genetic variants associated with early-onset colorectal cancer.

  22363440   cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue.

  22367214   Characterization of gene-environment interactions for colorectal cancer susceptibility loci.

  22457752   A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.

  22532847   Pooled sample-based GWAS: a cost-effective alternative for identifying colorectal and prostate cancer risk variants in the Polish population.

  22580541   Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer.

  22629442   Evaluation of allele-specific somatic changes of genome-wide association study susceptibility alleles in human colorectal cancers.

  22675446   Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.

  22848671   Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.

  22879968   Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese.

  22999960   Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.

  23104301   Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival.

  23125224   Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.

  23300701   Genome-wide search for gene-gene interactions in colorectal cancer.

  23350875   A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12.

  23434150   Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

  23875689   Colorectal cancer-susceptibility single-nucleotide polymorphisms in Korean population.

  23946381   Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.

  24086368   An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.

  24212777   Predictive and prognostic factors in colorectal cancer: a personalized approach.

  24448986   Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.

  24587672   New genes emerging for colorectal cancer predisposition.

  24705330   Architecture of inherited susceptibility to colorectal cancer: a voyage of discovery.

  24727911   Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.

  24764655   Genetic variations in colorectal cancer risk and clinical outcome.

  24801760   Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.

  24968322   Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population.

  25117299   Cumulative effects of genetic markers and the detection of advanced colorectal neoplasias by population screening.

  25873010   Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk.

  25956580   A colorectal cancer prediction model using traditional and genetic risk scores in Koreans.

  25963333   A subset of genetic susceptibility variants for colorectal cancer also has prognostic value.

  26078566   Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.

  26451011   Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.

  26779637   Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients?

  26880076   Colorectal cancer risk variants at 8q23.3 and 11q23.1 are associated with disease phenotype in APC mutation carriers.

  26940994   GWASeq: targeted re-sequencing follow up to GWAS.

  26989026   SMAD7 loci contribute to risk of hepatocellular carcinoma and clinicopathologic development among Chinese Han population.

  27078840   Genetic Variants Associated with Colorectal Adenoma Susceptibility.

  27146020   Colorectal cancer risk genes are functionally enriched in regulatory pathways.

  27207650   Genome-wide association study of colorectal cancer in Hispanics.

  27379672   Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.

  27424552   Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.

  27766137   Epidemiology of colorectal cancer.

  28070019   SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.

  28233817   Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study.

  28374902   Impact of microRNA-375 and its target gene SMAD-7 polymorphism on susceptibility of colorectal cancer.

  28467803   SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population.

  29084532   The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis.

  29547645   Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.

  30337837   Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis.

  31637880   MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis.

  31818908   Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

  32022527   Synchronous and multiple renal cell carcinoma, clear cell and papillary: An approach to clinically significant genetic abnormalities.

  32324875   Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants.

  32856881   Relationship between rs6715345 Polymorphisms of MIR-375 Gene and rs4939827 of SMAD-7 Gene in Women with Breast Cancer and Healthy Women: A Case-Control Study.

  33395643   [MODEL FOR PREDICTING THE PROGRESSION OF LIVER FIBROSIS BASED ON BIOCHEMICAL AND GENETIC CRITERIA IN PATIENTS WITH CHRONIC HEPATITIS C].

  33512737   A case-control study examining the association of smad7 and TLR single nucleotide polymorphisms on the risk of colorectal cancer in ulcerative colitis.

  35016683   Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk.