SNP information rs4646437

Research and publications:

  17465708   Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes.

  18825162   Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans.

  18978522   CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.

  19801957   The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.

  19846565   Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

  20386561   Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.

  21288825   Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.

  21544809   Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

  21896912   Population pharmacokinetic/pharmacogenetic model for optimization of efavirenz therapy in Caucasian HIV-infected patients.

  23064017   Donor ABCB1 variant associates with increased risk for kidney allograft failure.

  23609392   Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects.

  24884825   Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for pharmacogenomics.

  25171434   UGT1A1*28 is associated with greater decrease in serum K⁺ levels following oral intake of procaterol.

  25240575   Impact of CYP3A4 and MDR1 gene (G2677T) polymorphisms on dose requirement of the cyclosporine in renal transplant Egyptian recipients.

  25515945   Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole.

  25955319   Finasteride concentrations and prostate cancer risk: results from the Prostate Cancer Prevention Trial.

  26810136   Sunitinib-induced hypertension in CYP3A4 rs4646437 A-allele carriers with metastatic renal cell carcinoma.

  27720787   Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery.

  27937053   Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers.

  27940354   Pharmacogenetic association of MBL2 and CD95 polymorphisms with grade 3 infection following adjuvant therapy for breast cancer with doxorubicin and cyclophosphamide.

  28112181   IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients.

  28723497   Pharmacogenomic Markers of Targeted Therapy Toxicity in Patients with Metastatic Renal Cell Carcinoma.

  28787260   Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the α-adrenergic receptor antagonist.

  28952408   Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.

  29868865   Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals.

  30065912   Variants of FasL and ABCC5 are predictive of outcome after chemotherapy-based treatment in osteosarcoma.

  30392849   Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers.

  30910847   Association between CYP3A4 gene rs4646437 polymorphism and the risk of hypertension in Chinese population: a case-control study.

  31291311   Single nucleotide polymorphisms associated with elevated alanine aminotransferase in patients receiving asunaprevir plus daclatasvir combination therapy for chronic hepatitis C.

  31401678   CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic range proteinuria.

  31799230   Effects of CYP3A4 Polymorphisms on Drug Addiction Risk Among the Chinese Han Population.

  32126981   CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study.

  32464168   CYP3A4 genetic variants are associated with susceptibility of non-small cell lung cancer in a Shaanxi Han population.

  32738269   The effect of CYP3A4 genetic variants on the susceptibility to chronic obstructive pulmonary disease in the Hainan Han population.

  32780457   Pharmacogenetics for severe adverse drug reactions induced by molecular-targeted therapy.

  33124772   Impact of CYP2C19, CYP3A4, ABCB1, and FMO3 genotypes on plasma voriconazole in Thai patients with invasive fungal infections.

  33313130   Pharmacogenetic and safety analysis of cinacalcet hydrochloride in healthy Chinese subjects.

  33519226   Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.

  34113252   Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole.

  34117307   Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population.

  34688813   CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.

  34802160   Machine learning-based method for tacrolimus dose predictions in Chinese kidney transplant perioperative patients.

  35081606   Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients.