SNP information rs4537545

Research and publications:

  17671508   A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

  18276608   Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth

  19197348   Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

  19249341   Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

  19567438   Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

  20031577   New loci, including those associated with Crohn's disease, psoriasis and inflammation, were identified in a genome-wide association study of fibrinogen in 17,686 women: the Women's Genome Health Study.

  20978265   Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).

  21333900   The role of genetics in IBS

  21523452   Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.

  21552154   Common genetic variation in the IGF1 associates with maximal force output.

  21846873   Large-Scale Candidate Gene Analysis in Whites and African Americans Reveals IL6R Polymorphisms in Atrial Fibrillation: National Heart, Lung, and Blood Institute Candidate Gene Association Resource (CARe) Project of the National Institute

  22479352   The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.

  22492993   C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

  23101478   Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

  23386860   Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.

  24971461   Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.

  26198920   Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population.

  27327646   Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

  27417569   Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases.

  28769070   IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels.

  30651573   Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure.

  32382712   Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study.

  33517400   Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

  35493452   Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.