SNP information rs2943641

Research and publications:

  19734900   Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

  20043853   Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

  20081858   New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  20820957   The Genetics of Insulin Resistance: Where's Waldo?

  20862305   Identification of new genetic risk variants for type 2 diabetes.

  20886378   Physiologic characterization of type 2 diabetes-related loci

  21091714   The genetics of type 2 diabetes: what have we learned from GWAS?

  21188353   Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans

  21353221   The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.

  21442158   Genetic variants near the IRS1 gene, physical activity and type 2 diabetes in US men and women.

  21444075   Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

  21706003   Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

  21747052   Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

  21747906   Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans.

  21799836   A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.

  21848424   Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.

  21858135   Efficient replication of over 180 genetic associations with self-reported medical data.

  21917432   IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.

  22046406   Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese

  22237986   Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.

  22253814   A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.

  22576021   Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population.

  22617042   The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling.

  22971100   Quick, "imputation-free" meta-analysis with proxy-SNPs.

  23036851   Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors.

  23073174   From genotype to human β cell phenotype and beyond

  23185337   Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.

  23193118   Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium

  23418314   The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.

  23596181   Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries.

  23659870   Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study.

  24009303   IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention: the POUNDS LOST trial.

  24255076   Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641, and insulin resistance: replication of a gene-nutrient interaction in 4 populations of different ancestries.

  24392269   Gene-Lifestyle Interactions in Obesity.

  24493031   Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population.

  24864266   Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.

  24929251   Gene-carbohydrate and gene-fiber interactions and type 2 diabetes in diverse populations from the National Health and Nutrition Examination Surveys (NHANES) as part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study.

  25587982   Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.

  25658847   Do variants associated with susceptibility to pancreatic cancer and type 2 diabetes reciprocally affect risk?

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  26240488   Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.

  27053236   Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.

  27159875   Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus.

  27312935   Genetics of Insulin Resistance and the Metabolic Syndrome.

  27347941   Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes.

  27416945   Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

  27663718   Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.

  28696414   Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus.

  28821857   CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.

  30888963   Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina.

  31478326   Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.

  33038280   Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  33763108   Whole Genome Interpretation for a Family of Five.

  34480216   Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study.

  34801028   Association of single nucleotide polymorphisms with insulin secretion, insulin sensitivity, and diabetes in women with a history of gestational diabetes mellitus.

  36009479   COBLL1 and IRS1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.