Normal allele: CC
The AKT1 genotype affects the risk of developing psychosis in cannabis users. It also increases the risk of schizophrenia in people with a break in this gene.
Polymorphism rs2494732 is related to topics like this:
Research and publications:
16260726 Detection of functional single-nucleotide polymorphisms that affect apoptosis.
17464696 AKT1 and neurocognition in schizophrenia.
18715757 Genetic associations with schizophrenia: meta-analyses of 12 candidate genes
19461960 Absence of AKT1 mutations in glioblastoma.
20046382 AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia.
21061022 AKT1 polymorphisms are associated with risk for metabolic syndrome.
21728034 Methamphetamine-associated psychosis.
21775978 AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder.
21842521 AKT1 polymorphisms and survival of early stage non-small cell lung cancer.
22150081 The AKT1 gene is associated with attention and brain morphology in schizophrenia.
22831980 Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.
24803581 SNPs in PI3K-PTEN-mTOR and brain metastases in NSCLC--response.
24860514 Gene-environment interactions in severe mental illness.
24904437 Gone to Pot - A Review of the Association between Cannabis and Psychosis.
24944790 Screening for 392 polymorphisms in 141 pharmacogenes.
27018053 Progression and metastasis of lung cancer.
27187382 Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects.
27305091 Genetic Association of TCF4 and AKT1 Gene Variants with the Age at Onset of Schizophrenia.
27554198 Cannabis and a lower BMI in psychosis: What is the role of AKT1?
28900113 Abnormalities of signal transduction networks in chronic schizophrenia.
30093869 Biological Predictors of Clozapine Response: A Systematic Review.
30781715 Genetic Epidemiology of Breast Cancer in Latin America.
31445421 Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis.
32319007 Effects of the mTOR and AKT genes polymorphisms on systemic lupus erythematosus risk.
32536252 The effect of the AKT1 gene and cannabis use on cognitive performance in healthy subjects.
33107190 Effects of the MTOR and AKT1 genes polymorphisms on papillary thyroid cancer development.
33112820 Akt1 genetic variants confer increased susceptibility to thyroid cancer.