Normal allele: CC
gene is responsible for hepatic glycogen synthase, which catalyses the formation of glycogen from glucose in the liver. According to the study carriers of the minor allele C lost more weight than homozygotes for the major allele T in response to a keto diet (8-13% carbohydrate, 60-63% fat and 28-30% protein) over a period of 4-12 years. This suggests that the liver glycogen response to carbohydrate restriction may influence the weight loss response to the keto diet.
Polymorphism rs2306179 is related to topics like this:
Research and publications:
16700901 Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction.
18254975 Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat