SNP information rs2240340

Research and publications:

  16380915   Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4

  16519819   Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

  18087673   Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.

  18462498   Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking

  18466472   Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm

  18466513   Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15

  18466554   Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests

  18794853   Common variants at CD40 and other loci confer risk of rheumatoid arthritis

  19180477   Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations

  19470526   PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population.

  19898481   Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

  20075733   Recent advances in the genetics of rheumatoid arthritis.

  20233754   Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.

  20309765   Bagging optimal ROC curve method for predictive genetic tests, with an application for rheumatoid arthritis.

  20444268   Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20510233   Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

  20563870   The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population.

  21039740   PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.

  21698003   Investigating the pathogenic role of PADI4 in oesophageal cancer.

  21931699   Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.

  21980439   A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

  22505706   Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis.

  23164236   Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.

  23226040   Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies.

  23251581   Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades.

  23577190   PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study.

  24564960   Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort.

  25834819   TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

  26843965   Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.

  27092776   A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

  27111223   Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis.

  28182665   PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.

  28653215   NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.

  30044533   Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients.

  32163016   PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) gene polymorphisms and polyarticular juvenile idiopathic arthritis.

  33059697   rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis-a possible interface?

  34070522   Genetic Factors of Predisposition and Clinical Characteristics of Rheumatoid Arthritis in Russian Patients.

  35607828   Polymorphism of protein tyrosine phosphatase non-receptor type 22 and protein arginine deiminase 4 gene among Ghanaian rheumatoid arthritis patients: A case-control study.