SNP information rs16969968

Research and publications:

  17135278   Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

  18165968   Identification of pharmacogenetic markers in smoking cessation therapy

  18227835   Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking

  18385676   Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

  18385738   A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

  18385739   A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

  18414406   Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

  18519132   A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence

  18519524   Variants in nicotinic receptors and risk for nicotine dependence

  18565990   Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

  18571741   Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research

  18618000   A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction

  18759969   In search of causal variants: refining disease association signals using cross-population contrasts

  18780872   Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

  18783506   Association of single nucleotide polymorphisms in the neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and the “pleasurable high” during early smoking experiments.

  18957677   The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer

  18978134   Lung cancer gene associated with COPD: triple whammy or possible confounding effect?

  19005185   Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese

  19010884   Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine

  19029397   Nicotinic receptor gene variants influence susceptibility to heavy smoking

  19064933   Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans

  19132693   Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence

  19184766   A testable prognostic model of nicotine dependence

  19238175   New insights into the genetics of addiction

  19247474   Genome-wide and candidate gene association study of cigarette smoking behaviors

  19259974   Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

  19300482   A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci

  19330903   Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans

  19390575   Lung cancer susceptibility model based on age, family history and genetic variants

  19436041   Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

  19443489   Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

  19465454   The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19482438   Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence

  19492010   The genetic components of alcohol and nicotine co-addiction: from genes to behavior

  19596527   Nicotine dependence and genetic variation in the nicotinic receptors

  19628476   Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15

  19641473   Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  19733931   Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients

  19760673   Association of CHRN genes with "dizziness" to tobacco

  19776245   Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

  19789337   Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  19896728   Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25

  19944766   A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia

  20022891   The evolving discipline of molecular epidemiology of cancer

  20056643   A rigorous and comprehensive validation: common genetic variations and lung cancer

  20147892   Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence

  20159342   Genetics of addictions

  20395203   A second genetic variant on chromosome 15q24-25.1 associates with lung cancer

  20418889   Meta-analysis and imputation refines the association of 15q25 with smoking quantity

  20418890   Genome-wide meta-analyses identify multiple loci associated with smoking behavior

  20485328   Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes

  20529875   SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study

  20548021   Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium

  20554942   Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

  20581870   From smoking to lung cancer: the CHRNA5/A3/B4 connection

  20584212   Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

  20587604   Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans

  20624154   Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes

  20631687   Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility

  20643934   A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

  20656943   Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

  20691427   Genetic associations of brain structural networks in schizophrenia: a preliminary study

  20700436   Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

  20725741   Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity

  20736995   Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence

  20808433   Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population

  20832656   Genetics of addictions

  20840187   Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence

  20854418   CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences

  20886544   Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance

  20981002   Breaking barriers in the genomics and pharmacogenetics of drug addiction

  21079997   Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence

  21081471   Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study

  21168125   TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood

  21191315   Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene

  21193173   A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits

  21228559   A preliminary study of the CHRNA3-CHRNA5-CHRNB4 cluster, smoking and Parkinson's disease.

  21229299   Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

  21268243   Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy

  21304900   Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD

  21335511   A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

  21338875   Genetic vulnerability and susceptibility to substance dependence

  21385908   Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers

  21418140   A CHRNA5 allele related to nicotine addiction and schizophrenia

  21430647   The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment

  21436384   Genetic variability of smoking persistence in African Americans

  21440309   Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD

  21500120   Lung cancer in never smokers

  21559498   Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

  21593077   Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

  21606948   Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes

  21618602   Detecting genetic interactions for quantitative traits with U-statistics

  21685187   Genome-wide association study of smoking behaviours in patients with COPD

  21686075   The Role of Genetics in Nicotine Dependence: Mapping the Pathways from Genome to Syndrome

  21690317   CHRNA3 rs1051730 genotype and short-term smoking cessation

  21697764   Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer