When vitamin E is consumed, an increase in IL6 production is observed in carriers of this genotype, i.e. a pro-inflammatory effect is observed.
Research and publications:
15213713 A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer.
15726497 Gene-environment interaction effects on the development of immune responses in the 1st year of life
15817713 Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
16112301 NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
16582078 Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
17054776 The genetics of chronic obstructive pulmonary disease
17160896 Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.
17194543 Variants of the glutathione S-transferase classes mu, omega, pi, and theta and smoking in Parkinson's disease.
17363767 Genetic determinants of emphysema distribution in the national emphysema treatment trial.
17366837 Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada
17409936 Glutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer.
17424838 [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].
17498780 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.
17548691 Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
17601350 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
17885617 Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.
18182569 Pharmacogenetics of minimal residual disease in children with precursor acute lymphoblastic leukemia B: a report from the Children's Oncology Group.
18191955 Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools
18335111 Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis.
18449058 Maternal smoking and oral clefts: the role of detoxification pathway genes.
18547414 Genotyping panel for assessing response to cancer chemotherapy
18559526 Glutathione s-transferase p1: gene sequence variation and functional genomic studies.
18601742 Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
18628428 Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
18709160 Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease
18768509 Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
18776599 Susceptibility genes for gentamicin-induced vestibular dysfunction.
18784359 Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.
18787887 Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures
18805939 Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis
18854777 Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.
18988661 Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children.
18992148 Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study
19076156 Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
19124514 Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.
19131562 Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes.
19174490 Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.
19203783 Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: a Korean population-based study.
19223546 Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.
19258736 Glutathione s-transferase variants in a brazilian population.
19267064 [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].
19338043 Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma.
19376514 Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.
19383894 Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.
19403501 In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren.
19442035 Pharmacogenomics of platinum-based chemotherapy in NSCLC.
19498054 Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.
19568750 MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer.
19822571 Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma.
19826048 Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran
19899130 Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.
19921428 Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.
19922504 Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma.
19933216 The COPD genetic association compendium: a comprehensive online database of COPD genetic associations
19951401 Chronic obstructive pulmonary disease: towards pharmacogenetics
20029944 Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
20044584 Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk.
20049130 Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study.
20049212 Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).
20078613 Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients
20091863 Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.
20100738 Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.
20110814 Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution.
20131310 Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.
20233420 Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.
20413979 Testing haplotype-environment interactions using case-parent triads.
20436251 Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma.
20445800 Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.
20459744 Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.
20472488 GST polymorphisms, interactions with smoking and pesticide use, and risk of Parkinson's disease in a Japanese population.
20526719 GSTM1, GSTP1, and NQO1 polymorphisms and susceptibility to atopy and airway hyperresponsiveness among South African schoolchildren.
20530282 Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.
20540773 The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.
20568049 GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer.
20597111 Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.
20663217 Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
20673164 Genetic association studies of antioxidant pathway genes and schizophrenia.
20846924 Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors.
20847277 Genotyping of DNA samples isolated from formalin-fixed paraffin-embedded tissues using preamplification.
20935060 Genetic modifiers of carcinogen DNA adducts in target lung and peripheral blood mononuclear cells
20938339 Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.
21072184 Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
21164266 Glucocorticoid resistance.
21169260 Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer.
21179236 Analysis of candidate genes for macular telangiectasia type 2.
21320344 Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
21324477 Genetic biomarkers of health-related quality of life in pediatric asthma.
21362365 Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer.
21449681 Use of a comprehensive panel of biomarkers to predict response to a fluorouracil-oxaliplatin regimen in patients with metastatic colorectal cancer.
21454829 Evaluation of functional genetic variants for breast cancer risk: results from the Shanghai breast cancer study.
21474949 Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma.
21504558 Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study.
21514219 Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence
21532841 Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk.
21567099 Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer.
21595856 Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma.
21618522 Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk.
21669193 GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism.
21708280 Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis
