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SNP information rs1695

Normal allele: AA

When vitamin E is consumed, an increase in IL6 production is observed in carriers of this genotype, i.e. a pro-inflammatory effect is observed.

Polymorphism rs1695 is related to topics like this:

Vitamin E

Vitamin E is widely acknowledged for its crucial role in shielding cell components from oxidative...

Research and publications:

  15213713   A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer.

  15726497   Gene-environment interaction effects on the development of immune responses in the 1st year of life

  15817713   Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations

  16112301   NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.

  16582078   Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.

  17054776   The genetics of chronic obstructive pulmonary disease

  17160896   Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.

  17363767   Genetic determinants of emphysema distribution in the national emphysema treatment trial.

  17366837   Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada

  17409936   Glutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer.

  17424838   [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].

  17498780   The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.

  17548691   Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.

  17601350   A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

  17885617   Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.

  18191955   Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools

  18335111   Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis.

  18449058   Maternal smoking and oral clefts: the role of detoxification pathway genes.

  18547414   Genotyping panel for assessing response to cancer chemotherapy

  18559526   Glutathione s-transferase p1: gene sequence variation and functional genomic studies.

  18601742   Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.

  18628428   Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

  18709160   Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease

  18768509   Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.

  18776599   Susceptibility genes for gentamicin-induced vestibular dysfunction.

  18784359   Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.

  18787887   Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures

  18805939   Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis

  18854777   Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.

  18988661   Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children.

  18992148   Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

  19076156   Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

  19124514   Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.

  19131562   Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes.

  19174490   Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

  19203783   Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: a Korean population-based study.

  19223546   Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.

  19258736   Glutathione s-transferase variants in a brazilian population.

  19267064   [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].

  19338043   Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma.

  19376514   Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.

  19383894   Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.

  19403501   In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren.

  19442035   Pharmacogenomics of platinum-based chemotherapy in NSCLC.

  19498054   Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.

  19568750   MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer.

  19822571   Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma.

  19826048   Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran

  19899130   Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.

  19921428   Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.

  19922504   Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma.

  19933216   The COPD genetic association compendium: a comprehensive online database of COPD genetic associations

  19951401   Chronic obstructive pulmonary disease: towards pharmacogenetics

  20029944   Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.

  20044584   Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk.

  20049130   Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study.

  20049212   Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).

  20078613   Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients

  20091863   Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.

  20100738   Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.

  20110814   Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution.

  20131310   Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.

  20233420   Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.

  20413979   Testing haplotype-environment interactions using case-parent triads.

  20436251   Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma.

  20445800   Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.

  20459744   Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.

  20526719   GSTM1, GSTP1, and NQO1 polymorphisms and susceptibility to atopy and airway hyperresponsiveness among South African schoolchildren.

  20530282   Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.

  20540773   The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.

  20568049   GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer.

  20597111   Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.

  20663217   Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.

  20673164   Genetic association studies of antioxidant pathway genes and schizophrenia.

  20846924   Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors.

  20847277   Genotyping of DNA samples isolated from formalin-fixed paraffin-embedded tissues using preamplification.

  20935060   Genetic modifiers of carcinogen DNA adducts in target lung and peripheral blood mononuclear cells

  20938339   Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.

  21072184   Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.

  21164266   Glucocorticoid resistance.

  21169260   Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer.

  21179236   Analysis of candidate genes for macular telangiectasia type 2.

  21320344   Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

  21324477   Genetic biomarkers of health-related quality of life in pediatric asthma.

  21362365   Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer.

  21449681   Use of a comprehensive panel of biomarkers to predict response to a fluorouracil-oxaliplatin regimen in patients with metastatic colorectal cancer.

  21454829   Evaluation of functional genetic variants for breast cancer risk: results from the Shanghai breast cancer study.

  21474949   Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma.

  21504558   Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study.

  21514219   Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence

  21532841   Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk.

  21567099   Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer.

  21595856   Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma.

  21618522   Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk.

  21669193   GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism.

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

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