SNP information rs1421085

Research and publications:

  17496892   Variation in FTO contributes to childhood obesity and severe adult obesity.

  17658951   Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

  17928949   FTO polymorphisms in oceanic populations

  18159244   Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

  18218107   FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs

  18316358   Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.

  18379722   Variations in the FTO gene are associated with severe obesity in the Japanese

  18487448   Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population

  18551112   Replication of genetic effects of FTO polymorphisms on BMI in a Korean population.

  18572014   FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.

  18599522   FTO variants are associated with obesity in the Chinese and Malay populations in Singapore

  18647953   Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test

  18719664   The FTO gene is associated with adulthood obesity in the Mexican population

  19079261   Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  19151714   Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

  19153581   Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.

  19255736   Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

  19322589   Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study

  19557161   Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

  19818665   Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France.

  19876010   A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity

  20075150   Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

  20080751   Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

  20127379   From monogenic to polygenic obesity: recent advances.

  20309761   Genotype-based risk and pharmacogenetic sampling in clinical trials.

  20373279   FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study).

  20381893   The genetics of obesity: FTO leads the way.

  20404173   A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.

  20421936   Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

  20430937   Fine mapping of the association with obesity at the FTO locus in African-derived populations.

  20442772   Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

  20502638   Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

  20616199   Evaluation of genetic susceptibility loci for obesity in Chinese women.

  20664633   Lack of association between a new tag SNP in the FTO gene and BMI in Czech-Slavonic population.

  20703240   Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.

  20875147   Obesity and the brain: a possible genetic link.

  21076408   Overexpression of Fto leads to increased food intake and results in obesity.

  21102551   Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.

  21124985   Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.

  21150882   Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.

  21248310   Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004.

  21283731   FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

  21317302   FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.

  21318054   Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents.

  21573225   Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine.

  21637715   Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly.

  21651756   FTO gene polymorphisms and obesity risk: a meta-analysis.

  21720422   Differences in the heritability of growth and growth velocity during infancy and associations with FTO variants.

  21778217   Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study.

  21788373   The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.

  21976109   Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study.

  21986706   The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents.

  22043165   Genetics of Obesity: What have we Learned?

  22084931   Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia.

  22187296   Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.

  22189543   Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.

  22513296   Obesity susceptibility loci and dietary intake in the Look AHEAD Trial.

  22590636   Prevalence and determinants of metabolic syndrome among women in Chinese rural areas.

  22614171   Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

  22761283   Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study.

  22801903   Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.

  23101478   Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

  23136261   Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study.

  23236435   Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2.

  23577239   Genetics of obesity and type 2 diabetes in African Americans.

  23636237   Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.

  23799528   Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies.

  23849767   Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension.

  24106974   Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility.

  24278475   FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis.

  24607704   Ripple effects of developmental disabilities and mental illness on nondisabled adult siblings.

  24675148   The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy.

  24768648   FTO polymorphisms moderate the association of food reinforcement with energy intake.

  24863145   FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet.

  24879436   Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.

  24911064   Association of FTO polymorphisms with obesity and metabolic parameters in Han Chinese adolescents.

  24978468   Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.

  24992585   Polygenic risk predicts obesity in both white and black young adults.

  25074273   Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.

  25477898   Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.

  25542809   Common variations in the FTO gene and obesity in Thais: a family-based study.

  26287746   FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

  26392018   FTO association and interaction with time spent sitting.

  26440677   Association of FTO and IRX3 genetic variants to obesity risk in north India.

  26700404   Association of genetic variants in the FTO gene with metabolic syndrome: A case-control study in the Tunisian population.

  26726774   Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.

  26727462   Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study.

  26741700   Association of rs9939609 Polymorphism with Metabolic Parameters and FTO Risk Haplotype Among Tunisian Metabolic Syndrome.

  26833210   Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population.

  26907388   Association of FTO gene variants with fetal growth trajectories: results from a survey of women in Southampton.

  26961502   Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

  27064284   Hypomorphism of Fto and Rpgrip1l causes obesity in mice.

  27146691   Risk of obesity and metabolic syndrome associated with FTO gene variants discloses clinically relevant gender difference among Turks.

  27196486   FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population.

  27241637   Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?

  27336604   Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.

  27465381   Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts.

  27478388   Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population-A Mendelian Randomization Analysis.

  27538985   Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures.

  27547017   Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.