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SNP information rs121913461

RS121913461

Normal allele: TT

Polymorphism rs121913461 is related to topics like this:

Leukemia is it genetic

Acute myeloid leukemia (AML) is a diverse cancer that primarily impacts individuals aged 60 and...

Research and publications:

  11853795   BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study.

  11964322   High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance.

  12399961   Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy.

  14559829   Inhibition of wild-type and mutant Bcr-Abl by pyrido-pyrimidine-type small molecule kinase inhibitors.

  14745431   High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib.

  15256422   Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.

  15381060   Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia.

  18615627   Kinase domain point mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia emerge after therapy with BCR-ABL kinase inhibitors.

  19466505   High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.

  19652056   Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase.

  20367437   Mutations in ABL kinase domain are associated with inferior progression-free survival.

  20697894   Characteristics of BCR-ABL kinase domain point mutations in Chinese imatinib-resistant chronic myeloid leukemia patients.

  21505103   The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile.

  21562040   BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet.

  21895409   Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia.

  23676790   Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib.

  24456693   BCR-ABL kinase domain mutations, including 2 novel mutations in imatinib resistant Malaysian chronic myeloid leukemia patients-Frequency and clinical outcome.

  25157968   Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

Is drug abuse genetic

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Obesity genes

Although physical inactivity and consuming energy-dense foods are commonly identified as the main...

Psoriasis is a genetic disease

It is beneficial to comprehend the genetic impact on the molecular mechanisms and pathways that...

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