SNP information rs1121980

Research and publications:

  18159244   Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

  18256137   Regulation of Fto/Ftm gene expression in mice and humans

  18379722   Variations in the FTO gene are associated with severe obesity in the Japanese

  18454148   Common variants near MC4R are associated with fat mass, weight and risk of obesity

  18487448   Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population

  18599522   FTO variants are associated with obesity in the Chinese and Malay populations in Singapore

  19079261   Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  19164386   Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.

  19322589   Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19553294   Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.

  19584900   Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany

  19812171   Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.

  19822564   Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types

  20017965   Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.

  20017980   A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.

  20018076   Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort.

  20075932   Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese.

  20299471   FTO genetic variation and association with obesity in West Africans and African Americans.

  20442772   Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

  20724581   Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.

  20816195   Analyses of shared genetic factors between asthma and obesity in children.

  20824172   Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

  21102551   Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.

  21115529   Genetics and genomics of human ageing.

  21150882   Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.

  21248185   Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals.

  21267540   Genetic predisposition to obesity leads to increased risk of type 2 diabetes.

  21294771   An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.

  21489227   The role of the fat mass and obesity associated gene (FTO) in breast cancer risk.

  21552555   A genome-wide association study on obesity and obesity-related traits.

  21573225   Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine.

  21651756   FTO gene polymorphisms and obesity risk: a meta-analysis.

  21773002   Mendelian Randomisation Study of Childhood BMI and Early Menarche.

  21799482   Common genetic variants and central adiposity among Asian-Indians.

  21976109   Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study.

  22049296   A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.

  22084931   Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia.

  22189543   Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.

  22355368   Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood.

  22384102   A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study.

  22614171   Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

  22723994   Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach.

  22998931   Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT study.

  23094032   Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study.

  23236435   Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2.

  23626757   Development of GMDR-GPU for gene-gene interaction analysis and its application to WTCCC GWAS data for type 2 diabetes.

  23712987   Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study.

  23799528   Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies.

  24091943   Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk.

  24097068   Discovery and refinement of loci associated with lipid levels.

  24106974   Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility.

  24392269   Gene-Lifestyle Interactions in Obesity.

  24768648   FTO polymorphisms moderate the association of food reinforcement with energy intake.

  24879436   Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.

  25387436   Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview.

  25793382   Indications for potential parent-of-origin effects within the FTO gene.

  26445370   Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status – The HUNT Study.

  26642925   Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.

  26691922   Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.

  26726774   Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.

  27241637   Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?

  27478388   Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population-A Mendelian Randomization Analysis.

  27634552   Effects of MC4R, FTO, and NMB gene variants to obesity, physical activity, and eating behavior phenotypes.

  27820839   FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.

  27920511   Relationships between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study.

  28253266   Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.

  28954439   Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes.

  29273742   The interaction of fat mass and obesity associated gene polymorphisms and dietary fiber intake in relation to obesity phenotypes.

  29525920   Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS).

  30021629   Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs.

  30099472   Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Risk of Intervertebral Disc Degeneration in Chinese Han Population: A Case Control Study.

  30584432   Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

  30686248   Intron-specific Single Nucleotide Polymorphisms of Fat Mass and Obesity- Associated Gene in Obese and Overweight Individuals of the Indian Adult Population- A Pilot Study.

  30822753   Effects of fat mass and obesity-associated (FTO) gene polymorphisms on binge eating in women with binge-eating disorder: The moderating influence of attachment style.

  30929646   Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes.

  30954417   Evaluating the interaction of common FTO genetic variants, added sugar, and trans-fatty acid intakes in altering obesity phenotypes.

  31852448   Genome-wide association study of morbid obesity in Han Chinese.

  32384785   Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma.

  32390949   Genetic Susceptibility to Gestational Diabetes Mellitus in a Chinese Population.

  32598022   The FTO gene is not associated with weight gain during six years of observation in the population of the PURE study in Poland.

  32788640   Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS).

  32917775   Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

  33817272   Relationship of FTO gene variations with NAFLD risk in Chinese men.

  34594363   Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.

  35124268   Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.