Normal allele: GG
A break in the oxidative stress gene, increases the risk of developing asthma.
Polymorphism rs10517 is related to topics like this:
Research and publications:
18632753 Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
18936436 Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994
20049212 Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).
20663217 Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
23259684 Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.
24177223 Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns.
25545243 Oxidative stress-related genetic polymorphisms are associated with the prognosis of metastatic gastric cancer patients treated with epirubicin, oxaliplatin and 5-fluorouracil combination chemotherapy.
25729241 Interactive effect of smoking and NQO1 haplotypes on lung cancer risk.
26257249 Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves.
27740732 Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy.
30237583 An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor.
31854268 Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients.
34457036 Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517).