SNP information rs10499194

Research and publications:

  17982456   Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

  18794853   Common variants at CD40 and other loci confer risk of rheumatoid arthritis

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  18987647   Rheumatoid arthritis: a view of the current genetic landscape

  19165918   Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

  19165919   Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

  19169254   Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

  19292917   Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.

  19321514   6q23 polymorphisms in rheumatoid arthritis Spanish patients.

  19366996   Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis.

  19387456   Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.

  19401279   Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis.

  19417005   Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.

  19439038   Complex genetic association of 6q23 with autoimmune rheumatic conditions.

  19445664   Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19565500   Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

  19674979   Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

  19849816   Genetics of rheumatic disease.

  19898481   Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

  20018027   Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.

  20075733   Recent advances in the genetics of rheumatoid arthritis.

  20112363   The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.

  20338887   Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.

  20439292   Genetic variants in the prediction of rheumatoid arthritis.

  20441431   Recent advances in the genetics of systemic lupus erythematosus.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20510233   Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

  20511617   Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  21120996   Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.

  21156761   A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

  21211616   Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.

  21858135   Efficient replication of over 180 genetic associations with self-reported medical data.

  21980299   A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

  21980439   A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22355377   Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians.

  22402800   Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

  22661644   Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

  22770979   Presence of multiple independent effects in risk loci of common complex human diseases.

  23000205   Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.

  23133455   TNF-α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications?

  23161053   Polymorphism of the TNFAIP3 gene increases the risk of Behçet's disease in the Chinese Han population.

  23450725   Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.

  23463983   Polymorphisms of TNFAIP3 gene in a Chinese Han population with fuchs heterochromic iridocyclitis.

  23555688   TNFAIP3 gene polymorphisms in a Chinese Han population with Vogt-Koyanagi-Harada syndrome.

  24068971   Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.

  24069534   Genetics of psoriasis and pharmacogenetics of biological drugs.

  24884566   Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid arthritis in northern Chinese Han population.

  25674272   TNFAIP3 rs2230926 polymorphisms in rheumatoid arthritis of southern Chinese Han population: a case-control study.

  25684197   Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case-control cohort.

  25834819   TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

  26005883   Lack of association of TNFAIP3 and JAK1 with Bechsche's disease in a European population.

  26143186   Characteristics of A20 gene polymorphisms and clinical significance in patients with rheumatoid arthritis.

  26483964   Genomic Study of Cardiovascular Continuum Comorbidity.

  26613086   Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.

  26843965   Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.

  28448618   rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.

  28702029   Inflammation-Related Gene Polymorphisms Associated With Primary Immune Thrombocytopenia.

  29584776   Retraction: rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.

  31308453   TNFAIP3 genetic polymorphisms reduce ankylosing spondylitis risk in Eastern Chinese Han population.

  35088123   Genetics of rheumatoid arthritis.