SNP information rs4646903

Research and publications:

  16582078   Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.

  16949388   CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal.

  17116718   Dietary phytoestrogen intake is associated with reduced colorectal cancer risk

  17429315   Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival

  17603290   Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women.

  18268125   Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns.

  18449058   Maternal smoking and oral clefts: the role of detoxification pathway genes.

  18593984   Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18628428   Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

  18691756   Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.

  18763031   CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.

  18768509   Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.

  18805939   Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis

  18941913   Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.

  18990750   Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.

  19127255   Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

  19174490   Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

  19267064   [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].

  19276377   CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification.

  19387820   Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

  19479063   Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.

  19537956   CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women.

  19582785   Methods for detecting interactions between genetic polymorphisms and prenatal environment exposure with a mother-child design.

  19608585   Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer.

  19627379   Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes.

  19630952   Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.

  19650794   CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients.

  19679043   African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.

  19860743   Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns.

  19954069   [Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms].

  20878621   Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.

  20937634   Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk.

  20957336   CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda.

  21081473   Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.

  21270648   Renal cancer risk and occupational exposure to polycyclic aromatic hydrocarbons and plastics.

  21359562   Modulation of urinary polycyclic aromatic hydrocarbon metabolites by enzyme polymorphisms in workers of the German Human Bitumen Study.

  21407259   Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.

  21429951   Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

  21514219   Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21741876   Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.

  21847401   Risk factors and control strategies for the rapidly rising rate of breast cancer in Korea.

  21897271   Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure.

  21958689   Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.

  22200898   Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE).

  22215955   Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: Application of the additive model for cancer.

  22301281   Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk.

  22418777   Estrogen-related genes and their contribution to racial differences in breast cancer risk.

  22525558   Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population.

  22547312   Lack of an association human dioxin detoxification gene polymorphisms with endometriosis in Japanese women: results of a pilot study.

  22645715   Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study.

  22674470   Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.

  22678668   Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence.

  22888287   CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians.

  22949524   Gene-environment interaction in preterm delivery with special reference to organochlorine pesticides.

  22994552   Maternal variation in EPHX1, a xenobiotic metabolism gene, is associated with childhood medulloblastoma: an exploratory case-parent triad study.

  23107763   Host genetic risk factors for community-acquired pneumonia.

  23130019   Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.

  23178447   Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.

  23497168   Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.

  23528250   Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women.

  23661361   The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.

  23686565   Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.

  23848208   CYP1A1 gene polymorphisms and polycystic ovary syndrome risk: a meta-analysis and meta-regression.

  23852617   Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.

  23906684   Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants.

  23946381   Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.

  23959649   Ten years of progress in the Hokkaido birth cohort study on environment and child health: cohort profile - updated 2013.

  24068433   CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.

  24151610   Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers.

  24266295   Polymorphisms of genes involved in the biotransformation of polycyclic aromatic hydrocarbons and atherosclerosis.

  24281767   Hypospadias and variants in genes related to sex hormone biosynthesis and metabolism.

  24499375   Association of oxidative stress-related genes with idiopathic recurrent miscarriage.

  24657182   Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a North Indian population.

  24895604   Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease.

  24926919   Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample.

  25207010   Polymorphisms of cytochrome p450 genes in three ethnic groups from Russia.

  25233467   Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.

  25419409   CYP2E1 gene rs6413420 polymorphism was first found in the Bouyei ethnic group of China.

  25630554   Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.

  25719551   The role of genotypes that modify the toxicity of chemical mutagens in the risk for myeloproliferative neoplasms.

  25902778   Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.

  25928231   Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis.

  26166128   Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility: A Meta-Analysis.

  26451011   Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.

  26571237   Glutathione S-Transferase Gene Polymorphisms and Treatment Outcome in Cervical Cancer Patients under Concomitant Chemoradiation.

  26578427   CYP1A1 rs1048943 and rs4646903 polymorphisms associated with laryngeal cancer susceptibility among Asian populations: a meta-analysis.

  27061602   Cytochrome P450 1A1 gene polymorphisms and digestive tract cancer susceptibility: a meta-analysis.

  27090234   Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India.

  27188524   Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.

  27243113   The Effect of the CYP1A1*2A Allele on Colorectal Cancer Susceptibility in a British Population.

  27265845   The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP-SNP Interaction in Chinese Women.

  27383824   The association of CYP1A1 genetic polymorphisms and additional gene-gene interaction with ischemic stroke in the eastern Han of China.

  27384991   Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies.

  27655273   Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans.

  27894333   Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.

  27956118   Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence.

  28018104   CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms.

  28089731   Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine.