Normal allele: GG
Also known as cyclooxygenase-2 (Cox-2), is overexpressed (p<0.01) in autism spectrum disorders.
Polymorphism rs2745557 is related to topics like this:
Research and publications:
17609663 COX2 genetic variation, NSAIDs, and advanced prostate cancer risk.
18085997 Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.
18579107 Association between PTGS2 polymorphism and autism spectrum disorders in Korean trios.
18682823 Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.
19505919 Toll-like receptor signaling pathway variants and prostate cancer mortality
19560328 No association between the PPARG gene and schizophrenia in a British population.
19776642 Omega-3 fatty acids, genetic variants in COX-2 and prostate cancer.
19820421 The effect of genetic polymorphisms of cyclooxygenase 2 on acute pancreatitis in Turkey.
20621252 The genetics of vascular complications in diabetes mellitus.
21063235 PharmGKB summary: very important pharmacogene information for PTGS2.
21430300 Genetic polymorphisms in inflammation pathway genes and prostate cancer risk.
21705955 Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility.
22376259 Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development.
23272139 Association of the innate immunity and inflammation pathway with advanced prostate cancer risk.
25368279 Evaluation of the contribution of cyclooxygenase 2 genotypes to breast cancer in Taiwan.
26967244 Systematic meta-analyses of gene-specific genetic association studies in prostate cancer.
32100450 Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility.
33565113 Connection of COX-2 variants to ankylosing spondylitis susceptibility.