SNP information rs2279744

Research and publications:

  15550242   A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.

  16258005   Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome.

  16287156   Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer.

  17003841   The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.

  17360557   Haplotype structure and selection of the MDM2 oncogene in humans.

  17537232   Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients.

  17634539   MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma.

  17957785   Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk.

  18332046   A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients.

  18433484   Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene.

  18433491   MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians.

  18798306   Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population.

  19193430   Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer.

  19237173   Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomy.

  19302219   p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma.

  19442035   Pharmacogenomics of platinum-based chemotherapy in NSCLC.

  19470478   Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

  19497887   Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.

  19521721   Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms.

  19542078   TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.

  19707196   The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.

  19751436   Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients.

  19837266   TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.

  20200430   TP53, MDM2, NQO1, and susceptibility to cervical cancer.

  20447891   MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population.

  20452958   Single-nucleotide polymorphisms in the p53 signaling pathway.

  20587610   Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.

  20617153   Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia.

  20736372   Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma.

  20855462   Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.

  20922573   Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus.

  20979563   Polymorphism of the MDM2 and CDKN1A genes and the risk of developing Kaposi's sarcoma in African and Caucasian patients.

  21051655   MDM2 as a modifier gene in retinoblastoma.

  21240526   Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.

  21268124   MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese.

  21305319   Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.

  21402718   Regulation of female reproduction by p53 and its family members.

  21437228   Using epidemiology and genomics to understand osteosarcoma etiology.

  21514219   Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence

  21540763   Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck.

  21619704   A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma.

  21656578   Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.

  21779510   Regulation of Fertility by the p53 Family Members.

  21841506   Combined effect of genetic polymorphisms in P53, P73, and MDM2 on non-small cell lung cancer survival.

  21877955   Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.

  22004425   Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study.

  22052649   Combined p53-related genetic variants together with HPV infection increase oral cancer risk.

  22180099   Influence of MDM2 and MDM4 on development and survival in hereditary retinoblastoma.

  22251423   NAMPT (visfatin) and AKT1 genetic variants associate with myocardial infarction.

  22300735   Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors.

  22347493   Genetic variation in cell death genes and risk of non-Hodgkin lymphoma.

  22916154   Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.

  23145162   Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma.

  23210739   Association of MDM2 and p53 polymorphisms with the advancement of cervical carcinoma.

  23218882   Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma.

  23244604   Identification of functional DNA variants in the constitutive promoter region of MDM2.

  23423487   Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy.

  23697595   SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers.

  23820649   Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

  24061636   Murine double minute 2 rs2279744 polymorphism and hepatocellular carcinoma risk in East Asians: a meta-analysis.

  24122202   Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systemic review and meta-analysis.

  24205329   Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data.

  24293392   MDM2 rs2279744 polymorphism and endometrial cancer: a meta-analysis.

  24340057   Genetic variations in radiation and chemotherapy drug action pathways and survival in locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.

  24435975   p53 signaling pathway polymorphisms associated to recurrent pregnancy loss.

  24586820   Evidence for an epistatic effect between TP53 R72P and MDM2 T309G SNPs in HIV infection: a cross-sectional study in women from South Brazil.

  24654968   Germline genetics of the p53 pathway affect longevity in a gender specific manner.

  24792886   Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies.

  24797837   MDM2 SNP309 polymorphism is associated with colorectal cancer risk.

  25054017   Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk.

  25214541   A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage.

  25316267   TP53 and MDM2 polymorphisms and the risk of endometrial cancer in postmenopausal women.

  25366142   Impact of MDM2 gene polymorphism on sarcoma risk.

  25412941   Association between polymorphisms in tumor suppressor genes and oncogenes and risk of hepatocellular carcinoma: a case-control study in an HCC epidemic area within the Han Chinese population.

  25431177   Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.

  25479941   Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population.

  25511444   Age-dependent association of MDM2 promoter polymorphisms and uterine leiomyoma in South-East Iran: A preliminary report.

  25734904   Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal adenocarcinoma.

  25928231   Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis.

  26025918   MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer.

  26135929   A Systematic Review and Meta-Analysis of Three Gene Variants Association with Risk of Prostate Cancer: An Update.

  26224627   Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis.

  26289323   Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.

  26382048   Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.

  26471763   MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.

  26672516   Association between MDM2 SNP309 T>G polymorphism and the risk of bladder cancer: new data in a Chinese population and an updated meta-analysis.

  26867771   The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.

  26945408   Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.

  26967244   Systematic meta-analyses of gene-specific genetic association studies in prostate cancer.

  27228500   Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma.

  27246533   The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC.

  27330794   Association of MDM2 promoter T309G polymorphism with oral cancer risk: A meta-analysis of 3,536 subjects.

  27438225   A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility.

  27506496   A Functional Polymorphism (rs937283) in the MDM2 Promoter Region is Associated with Poor Prognosis of Retinoblastoma in Chinese Han Population.

  27588484   Gene-gene interactions in gastrointestinal cancer susceptibility.

  27608007   Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients.

  27624283   MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.

  27785069   Influence of MDM2 polymorphisms on squamous cell carcinoma susceptibility: a meta-analysis.

  27801956   Mutations in apoptotic genes and micronucleus occurrence in vinyl chloride-exposed workers in China.

  28083704   MDM2 gene polymorphism and the risk of classical Kaposi's sarcoma among Iranian patients.