If you tested your DNA with a personal genomics service like 23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage or another testing company, you can learn more about your risk factors for hundreds of diseases. By clicking the button above ⬆️, you can upload your raw DNA data file and receive a personalized 250-page health report with research links that is the most comprehensive.
Our latest inclusion in the health report is the Type 1 Diabetes Genetic Risk Score, aimed at pinpointing individuals suitable for genetic testing for monogenic diabetes in cases where clinical features and autoimmune markers present ambiguity. This report offers autonomous insights for autoantibody and C-peptide testing, ensuring consistency as a DNA-based test, with results remaining constant over time.
Type 1 diabetes is a polygenic disease and common genetic variants have been identified that contribute to type 1 diabetes susceptibility. We genotype these variants and combine the risk of the individual variants that are present in a person to create a composite score that reflects an individual’s genetic susceptibility to type 1 diabetes.
On our website where you can easily upload raw DNA data file. This enables you to obtain a personalized health DNA report regarding T1D completely free of charge.
The likelihood of a patient having type 1 diabetes is based on the clinical information provided and the type 1 diabetes genetic risk score.
Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Type 1 diabetes and see a list of existing studies.
SNP polymorphisms related to the topic Type 1 diabetes:
| rs689 | A break in the INS insulin gene associated with the occurrence of type 1 and type 2 diabetes. |
| rs229541 | A predisposition locus for type 1 diabetes and celiac disease. |
| rs237025 | The gene for ubiquitin-like modifier 4 (SUMO4) predisposition to type 1 diabetes. |
| rs425105 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs478582 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs725613 | Variation in the CLEC16A gene shows a consistent disease association with both multiple sclerosis and type 1 diabetes. |
| rs757411 | |
| rs763361 | rs763361, also known as Gly307Ser, is a SNP in the CD226 immune response gene. It is associated with an increased risk of multiple autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. |
| rs917997 | |
| rs947474 | |
| rs1004446 | |
| rs1464510 | Common genetic variant in type 1 diabetes and celiac disease. |
| rs1465788 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs1701704 | Genetic variation associated with autoantibodies to insulin. |
| rs1738074 | Common genetic variant in type 1 diabetes and celiac disease. |
| rs1893217 | The PTPN2 risk gene is associated with Crohn's disease and type 1 diabetes. |
| rs1990760 | Associated with type 1 diabetes mellitus, organ-specific autoimmune diseases including Graves' disease. |
| rs2040410 | One of two polymorphisms (rs2040410 and rs7454108) that determine the highest risk of type 1 diabetes. |
| rs2069762 | |
| rs2069763 | Increased risk of autoimmune diseases - systemic lupus erythematosus, vasculitis, celiac disease, and newly diagnosed diabetes mellitus after transplantation. |
| rs2104286 | Genetic heterogeneity of IL2RA indicates susceptibility to multiple sclerosis and susceptibility to type 1 diabetes. |
| rs2290400 | increased risk of autoimmune diabetes in adults. |
| rs2292239 | The PTPN22 gene polymorphism associated with type 1 diabetes is related to the frequency of circulating regulatory T cells. |
| rs2296336 | |
| rs2476601 | This important SNP, located in the PTPN22 gene and also known as R620W or 1858C>T, may influence the risk of multiple autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, autoimmune thyroiditis and systemic lupus erythematosus. |
| rs2542151 | 2-fold risk of developing Crohn's disease and 1.6-fold for type 1 diabetes. |
| rs2544677 | |
| rs2639703 | |
| rs2664170 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs2816316 | Genetic variant risk for type 1 diabetes and gluten disease. |
| rs3024505 | Predisposition variants for ulcerative colitis, Crohn's disease and type 1 diabetes. |
| rs3087243 | The CTLA4 allelic variant alters T cell phosphorylation patterns and causes an increased risk of autoimmune diseases. |
| rs3129934 | |
| rs3184504 | A variant of celiac disease genetic risk associated with immune response. Also carrier associated type 1 diabetes. |
| rs3741208 | |
| rs3746722 | |
| rs3772534 | SNP rs3772534 in the CBLB gene indicates an increased risk of developing type 1 diabetes. |
| rs3788013 | A risk factor for islet autoimmunity and type 1 diabetes, as well as celiac disease, systemic lupus erythematosus and rheumatoid arthritis. |
| rs3825932 | Polymorphism of susceptibility to type 1 diabetes and celiac disease. |
| rs4763879 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs4788084 | Polymorphism of increased risk of adult autoimmune diabetes and diabetic retinopathy. |
| rs4900384 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs5753037 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs6441961 | Increased risk of gluten disease. |
| rs6679677 | An allelic variant of the PHTF1 gene is associated with a 5.2-fold increased risk of type 1 diabetes and a 3.3-fold increased risk of rheumatoid arthritis. |
| rs6822844 | Combined with the rs13119723 breakage, the study showed the strongest association with celiac disease among Caucasian patients. |
| rs6897932 | Variation in the IL7RA gene accounts for susceptibility to multiple sclerosis and type 1 diabetes. |
| rs7202877 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs7454108 | One of two polymorphisms (rs2040410 and rs7454108) that determine the highest risk of type 1 diabetes. |
| rs7528684 | |
| rs7574865 | 1.3-fold risk of rheumatoid arthritis |
| rs7804356 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs9272346 | HLA-DQA1 breakage is associated with a significant increase in risk (18-fold increase) of type 1 diabetes. |
| rs9388489 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs9811792 | |
| rs10517086 | Increased risk of islet autoimmunity and type 1 diabetes. |
| rs11052552 | |
| rs11171739 | Genetically dependent expression of ERBB3 modulates antigen-presenting cell function and risk of type 1 diabetes. |
| rs11571316 | Influences predisposition to diabetes and progression from prediabetes to diabetes in at-risk individuals. |
| rs11594656 | IL2RA gene polymorphism increases susceptibility to type I diabetes 1.19-fold for heterozygotes (AT) and 1.38-fold for homozygotes. |
| rs11755527 | Genetic predisposition between three autoimmune diseases: rheumatoid arthritis, type 1 diabetes and gluten disease. |
| rs12708716 | Polymorphisms influence the risk of developing type 1 diabetes. |
| rs12722495 | IL2RA gene polymorphism associated with type 1 diabetes. |
| rs17166496 | |
| rs17388568 | Genetic predisposition to insulin-dependent type 1 diabetes. |
| rs17696736 | 1.94-fold risk of insulin-dependent type 1 diabetes. |
| rs17810546 | Common genetic variant in type 1 diabetes and celiac disease. |
| rs41295061 | Genetic predisposition to type 1 diabetes and autoimmune thyroiditis. |
| rs45450798 | Polymorphisms affecting the disease process in type 1 diabetes and celiac disease. |