SNP information rs684513

Research and publications:

  17135278   Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

  17373692   No evidence for association between 19 cholinergic genes and bipolar disorder.

  18163978   The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

  18165968   Identification of pharmacogenetic markers in smoking cessation therapy

  18414406   Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

  18519524   Variants in nicotinic receptors and risk for nicotine dependence

  18571741   Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research

  19029397   Nicotinic receptor gene variants influence susceptibility to heavy smoking

  19132693   Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence

  19443489   Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  20212321   Multiplicity-calibrated Bayesian hypothesis tests.

  20418890   Genome-wide meta-analyses identify multiple loci associated with smoking behavior

  20485328   Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes

  20554942   Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

  20631687   Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility

  20700436   Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

  20854418   CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences

  20886544   Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance

  21191315   Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene

  21430647   The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment

  21685187   Genome-wide association study of smoking behaviours in patients with COPD

  21748402   A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.

  21808284   Gender-stratified gene and gene-treatment interactions in smoking cessation.

  22042234   Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.

  22048466   Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.

  22241830   Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

  22382757   The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.

  22539395   Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

  23358500   Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content.

  24186853   Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

  24588897   CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.

  24667010   Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome.

  25036316   Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

  25051068   Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.

  25642160   Nicotinic receptor modulation to treat alcohol and drug dependence.

  25874685   CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.

  25941207   An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School.

  26351737   Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use.

  26981579   Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.

  34555889   Association Study of Polymorphisms in Neuronal Nicotinic Acetylcholine Receptor Subunit Genes With Schizophrenia in the Han Chinese Population.