SNP information rs6495309

Research and publications:

  17373692   No evidence for association between 19 cholinergic genes and bipolar disorder.

  19330903   Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans

  19491260   Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations.

  19628476   Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  20485328   Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes

  20554942   Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

  20808433   Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population

  21081471   Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study

  21168125   TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood

  21229299   Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

  21487324   Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.

  21559498   Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

  21808284   Gender-stratified gene and gene-treatment interactions in smoking cessation.

  21949713   Genetics of sputum gene expression in chronic obstructive pulmonary disease.

  22048466   Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.

  22404340   Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population.

  22899653   Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

  23029550   Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966.

  23056235   Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.

  23255854   A functional polymorphism in the CHRNA3 gene and risk of chronic obstructive pulmonary disease in a Korean population.

  23397474   Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population.

  23689675   Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.

  23872218   Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.

  23943838   Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.

  24667010   Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome.

  24686516   CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population.

  25051068   Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.

  25233467   Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.

  25288178   The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk in Chinese: a meta-analysis.

  25302169   Acetylcholine receptor pathway in lung cancer: New twists to an old story.

  26831765   Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis.

  26981122   The Oncogenic Functions of Nicotinic Acetylcholine Receptors.

  27050379   Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer.

  27162544   Combining Telomerase Reverse Transcriptase Genetic Variant rs2736100 with Epidemiologic Factors in the Prediction of Lung Cancer Susceptibility.

  27230571   Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

  28181565   Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci.

  28474623   IREB2, CHRNA5, CHRNA3, FAM13A & hedgehog interacting protein genes polymorphisms & risk of chronic obstructive pulmonary disease in Tatar population from Russia.

  28827732   Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.

  29416783   Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the associated with the risk of non-small cell lung cancer.

  32104210   Inherited lung cancer: a review.

  33578531   The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review.

  34540891   Umbrella Review on Associations Between Single Nucleotide Polymorphisms and Lung Cancer Risk.