SNP information rs6495308

Research and publications:

  18165968   Identification of pharmacogenetic markers in smoking cessation therapy

  18227835   Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking

  18414406   Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

  18519524   Variants in nicotinic receptors and risk for nicotine dependence

  18571741   Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research

  19132693   Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence

  19259974   Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

  19443489   Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  19741265   Genetics and genomics of chronic obstructive pulmonary disease.

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  20393456   Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.

  20418889   Meta-analysis and imputation refines the association of 15q25 with smoking quantity

  20700436   Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

  20736995   Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence

  20808433   Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population

  21228559   A preliminary study of the CHRNA3-CHRNA5-CHRNB4 cluster, smoking and Parkinson's disease.

  21748402   A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.

  22102793   GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS.

  22223462   Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort.

  22539395   Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

  22544838   From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.

  22899653   Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

  23024249   Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.

  23143843   Molecular mechanisms underlying behaviors related to nicotine addiction.

  23536134   Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

  23691092   Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.

  23692359   CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

  23943838   Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.

  24339136   Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants.

  25036316   Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

  25632390   Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study.

  25778907   The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.

  25874685   CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.

  26695521   Is Mendelian Randomization the Key to Understanding Causal Aspects of Parkinson's Disease?

  26942719   Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.

  26948517   Genetic scores of smoking behaviour in a Chinese population.

  27127891   Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.

  27166759   Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

  27335628   A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania.

  27827986   Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.

  29751336   The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers.

  30453884   Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.