Normal allele: CC
Polymorphism rs4537545 is related to topics like this:
Cancer of the hematopoietic system
Research and publications:
17671508 A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.
18276608 Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth
19197348 Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
19249341 Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults
19567438 Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
20978265 Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).
21333900 The role of genetics in IBS
21523452 Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.
21552154 Common genetic variation in the IGF1 associates with maximal force output.
22479352 The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.
22492993 C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.
23101478 Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.
23386860 Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
24971461 Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.
26198920 Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population.
27327646 Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.
27417569 Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases.
28769070 IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels.
30651573 Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure.
32382712 Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study.
33517400 Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
35493452 Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.