Normal allele: CC
A functional variant of the microRNA-146a promoter modulates its expression and increases the risk of systemic lupus erythematosus.
Polymorphism rs2431697 is related to topics like this:
Research and publications:
19440199 Recent insights into the genetic basis of systemic lupus erythematosus.
20953187 Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
21068098 Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.
21408207 Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
21738483 A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
22174698 A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.
22218224 Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
23252691 Investigation of 20 non-HLA (human leucocyte antigen) psoriasis susceptibility loci in Chinese patients with psoriatic arthritis and psoriasis vulgaris.
24803388 Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis.
24991086 Novel insights into miRNA in lung and heart inflammatory diseases.
25008481 Prognostic role of MIR146A polymorphisms for cardiovascular events in atrial fibrillation.
25034154 Clinical perspectives on lupus genetics: advances and opportunities.
25369137 A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.
26251230 Association between rs2431697 T allele on 5q33.3 and systemic lupus erythematosus: case-control study and meta-analysis.
26366721 Common MIR146A Polymorphisms in Chinese Ankylosing Spondylitis Subjects and Controls.
27635407 Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?
27906046 Chromatin landscapes and genetic risk in systemic lupus.
28470127 Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis.
28489066 Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease.
28617847 The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci.
29437577 MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial Fibrillation.
29902229 miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis.
31235484 Association of microRNAs genes polymorphisms with arthritis: a systematic review and meta-analysis.
32107471 miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk.
32586906 miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis.
32929657 Genetic variants of microRNA-146a gene: an indicator of systemic lupus erythematosus susceptibility, lupus nephritis, and disease activity.
33294994 Associations between common genetic variants in microRNAs and Hirschsprung disease susceptibility in Southern Chinese children.
33420081 SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression.
33907143 Meta-analysis of association of microRNAs genetic variants with susceptibility to rheumatoid arthritis and systemic lupus erythematosus.
34060972 Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis.
34449663 Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine.
34837916 Predictive Value of miR-146a rs2431697 Polymorphism to Myelofibrosis Progression in Patients with Myeloproliferative Neoplasm.
35756164 mir-146a genetic polymorphisms in systemic lupus erythematosus patients: Correlation with disease manifestations.
35887682 MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction.