Normal allele: GG
The gene variant alters hepcidin but not plasma iron in response to oral iron administration in healthy adults. Hepcidin is a peptide hormone, a universal humoral regulator of plasma iron concentration and distribution in tissues.
Polymorphism rs2235321 is related to topics like this:
Research and publications:
25741868 Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.
28487959 Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
30593316 [Association between the polymorphisms of TMPRSS6 and the levels of serum ferrtin and soluble transferrin receptor in pregnant women in Lüliang Area of Shanxi Province].
33817543 Common Variants in the TMPRSS6 Gene Alter Hepcidin but not Plasma Iron in Response to Oral Iron in Healthy Gambian Adults: A Recall-by-Genotype Study.
33850216 Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in healthy rural Gambians.