SNP information rs2187668

Research and publications:

  15747258   A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.

  17558408   A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

  17997607   Identification of two independent risk factors for lupus within the MHC in United Kingdom families.

  18311140   Newly identified genetic risk variants for celiac disease related to the immune response.

  18509540   Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.

  18832704   Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis.

  19176549   Genome-wide association analysis by lasso penalized logistic regression.

  19455305   No association of multiple type 2 diabetes loci with type 1 diabetes

  19458622   Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.

  19846760   Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

  20176734   Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.

  20190752   Multiple common variants for celiac disease influencing immune gene expression.

  20398668   Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study.

  21049023   A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis.

  21266329   Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.

  21323541   Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

  21379322   Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.

  21383967   Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

  21408207   Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

  21533023   Adaptations to climate-mediated selective pressures in humans.

  21614020   The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus.

  21831970   Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.

  21854684   Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results.

  21873553   Genetic analysis of adult-onset autoimmune diabetes.

  22025780   FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.

  22077970   Abundant pleiotropy in human complex diseases and traits.

  22511809   Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.

  22541939   Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

  22654485   Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.

  23049788   Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

  23194743   Development of a high resolution melting method for genotyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these risk alleles.

  23936387   A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.

  24768677   Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.

  24876751   Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients.

  24946689   Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

  25034154   Clinical perspectives on lupus genetics: advances and opportunities.

  25827949   Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus.

  25829454   Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.

  25920553   Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.

  26324017   Immunogenetics of systemic lupus erythematosus: A comprehensive review.

  26413272   Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine.

  26606652   Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

  26652023   Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.

  26798662   Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype.

  27449795   Shared and unique common genetic determinants between pediatric and adult celiac disease.

  27871254   Familial aggregation of albuminuria and arterial hypertension in an Aboriginal Australian community and the contribution of variants in ACE and TP53.

  28056976   A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

  28685717   Variants in the Promoter Region of HLA-DQA1 were Associated with Idiopathic Membranous Nephropathy in a Chinese Han Population.

  28849274   Analysis of PLA2R1 and HLA-DQA1 sequence variants in Japanese patients with idiopathic and secondary membranous nephropathy.

  30383665   Association between the HLA-DQA1 rs2187668 polymorphism and risk of idiopathic membranous nephropathy: A PRISMA-compliant meta-analysis.

  30467913   Interaction between PLA2R1 and HLA-DQA1 variants contributes to the increased genetic susceptibility to membranous nephropathy in Western China.

  30972159   Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus.

  31426789   Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans.

  32753608   Single-nucleotide polymorphism rs4664308 in PLA2R1 gene is associated with the risk of idiopathic membranous nephropathy: a meta-analysis.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  33262486   Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

  33623956   PLA2R1 and HLA-DQA1 gene variations in idiopathic membranous nephropathy in South China.

  33763108   Whole Genome Interpretation for a Family of Five.

  34172490   The High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Polymorphisms Are Differentially Associated With Growth and IGF-I Levels in Infancy: The Cambridge Baby Growth Study.

  34607530   Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy.