Normal allele: TT
The IRGM rs13361189 polymorphism may contribute to Crohn's disease susceptibility.
Polymorphism rs13361189 is related to topics like this:
Research and publications:
19140132 Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
19491842 Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.
19750224 Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
20177049 Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.
20228799 Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
21049557 NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
21304977 An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
21333900 The role of genetics in IBS
21936032 Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.
21978003 Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.
22713085 IRGM gene polymorphisms and risk of gastric cancer.
23365659 IRGM variants and susceptibility to inflammatory bowel disease in the German population.
23844243 GStream: improving SNP and CNV coverage on genome-wide association studies.
24264476 Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines.
24859836 Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions.
24956270 Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants.
25191865 Association of IRGM gene mutations with inflammatory bowel disease in the Indian population.
25369137 A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.
25664588 Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.
25944217 Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.
26993061 Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.
27306066 Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis.
27417217 Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
28983640 A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis.
29228965 Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.
29992164 Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases.
30568945 Genetic associations of inflammatory bowel disease in a South Asian population.
30597691 The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.
33147747 Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.
35349414 Fever in systemic lupus erythematosus: associated clinical features and genetic factors.
35699756 Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis.