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The production of the sodium (Na)-iodide symporter or NIS protein is directed by the SLC5A5 gene. Its primary function involves facilitating iodide transportation, which is a negatively charged variant of iodine that enters cells in certain tissues. The thyroid gland contains most of this protein; it's shaped like a butterfly and located at the lower neck region. For regulating growth brain development and metabolic rate, thyroid hormones containing iodides are produced and released from within thyroids When consuming an adequate amount of nourishment enriched with Iodine ,NIS proteins work smoothly to ensure proper accumulation right inside thyroids for efficient hormone creation .Follicular cells known as particular Thyroid Cells rely on NIS' correct positioning along their cell membrane while ferrying bloodborne limit into them via naive electrochemistry option.
Apart from being present in the thyroid gland, the NIS protein is also detectable in breast tissue during lactation, ovaries, salivary glands, specific stomach cells (parietal cells), tear-producing glands (lacrimal glands), and a brain region known as choroid plexus. When milk production occurs during lactation period, the NIS protein aids iodide transportation into the milk to fulfill infant's thyroxine hormone requirement.
Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Iodine and see a list of existing studies.
SNP polymorphisms related to the topic Iodine:
| rs1126799 | Polymorphism in the thyroid peroxidase gene, is associated with the development of autoimmune thyroid disease and serum levels of thyroid peroxidase antibodies. |
| rs1567919 | |
| rs2048722 | Polymorphism in the thyroid peroxidase gene, is associated with the development of autoimmune thyroid disease and serum levels of thyroid peroxidase antibodies. |
| rs2071403 | The phosphodiesterase gene is associated with serum TTG levels and thyroid function. |
| rs4927606 | |
| rs4927608 | |
| rs6588678 | |
| rs6732480 | |
| rs7602332 | |
| rs10519477 | |
| rs11694726 | |
| rs13398180 | |
| rs13424221 | |
| rs13431646 | |
| rs45602038 | Sodium iodide symporter gene polymorphism, increases the likelihood of developing thyroid cancer. |